Mullerian inhibiting substance type II receptor as a potential target for antineoplastic therapy

   
Rak A.Ya.1 , Trofimov A.V.2, Ischenko A.M.2

1. State Research Institute of Highly Pure Biopreparations, Saint-Petersburg, Russia; Saint-Petersburg State University, Saint-Petersburg, Russia
2. State Research Institute of Highly Pure Biopreparations, Saint-Petersburg, Russia
Section: Review
DOI: 10.18097/PBMC20196503202      PubMed Id: 31258143
Year: 2019  Volume: 65  Issue: 3  Pages: 202-213
The review considers properties of the type II anti-Mullerian hormone receptor (mullerian inhibiting substance receptor type II, MISRII), a transmembrane sensor with its own serine/threonine protein kinase activity, triggering apoptosis of the Mullerian ducts in mammalian embryogenesis and providing formation of the male type reproductive system. According to recent data, MISRII overexpression in the postnatal period is found in cells of a number of ovarian, mammary gland, and prostate tumors, and anti-Mullerian hormone (AMH) has a pro-apoptotic effect on MISRII-positive tumor cells. This fact makes MISRII a potential target for targeted anti-cancer therapy. Treatment based on targeting MISRII seems to be a much more effective alternative to the traditional one and will significantly reduce the drug dose. However, the mechanism of MISRII-AMH interaction is still poorly understood, so the development of new anticancer drugs is complicated. The review analyzes MISRII molecular structure and expression levels in various tissues and cell lines, as well as current understanding of the AMH binding mechanisms and data on the possibility of using MISRII as a target for the action of AMH-based antineoplastic drugs.
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Keywords: AMHR2, anti-Mullerian hormone, antineoplastic therapy, MISRII, receptor, signaling pathway
Citation:

Rak, A. Ya., Trofimov, A. V., Ischenko, A. M. (2019). Mullerian inhibiting substance type II receptor as a potential target for antineoplastic therapy. Biomeditsinskaya khimiya, 65(3), 202-213.
This paper is also available as the English translation: 10.1134/S1990750819030053
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