The experimental study in vivo was aimed at evaluation of hypolipidemic action of the original natural microbial enzyme preparation of cholesterol oxidase (CHO). In preliminary chronic experiments in rats, rabbits, dogs, low toxicity, good tolerability, and anti-atherosclerotic activity of the CHO preparation were established. To assess the effect of CHO under conditions of moderate, nutritional, atherogenic dyslipoproteinemia, experiments were carried out in rats, guinea pigs, and rabbits. It was shown that administration of CHO had the pronounced lipid-lowering effect in models of atherogenic dyslipoproteinemia induced in these animals.
Klyueva N.N., Okunevich I.V., Parfenova N.S., Belova E.V., Ageeva E.V. (2019) Effect of lipid-lowering activity of the natural original enzyme preparation in the experiment. Biomeditsinskaya Khimiya, 65(3), 227-230.
Klyueva N.N. et al. Effect of lipid-lowering activity of the natural original enzyme preparation in the experiment // Biomeditsinskaya Khimiya. - 2019. - V. 65. -N 3. - P. 227-230.
Klyueva N.N. et al., "Effect of lipid-lowering activity of the natural original enzyme preparation in the experiment." Biomeditsinskaya Khimiya 65.3 (2019): 227-230.
Klyueva, N. N., Okunevich, I. V., Parfenova, N. S., Belova, E. V., Ageeva, E. V. (2019). Effect of lipid-lowering activity of the natural original enzyme preparation in the experiment. Biomeditsinskaya Khimiya, 65(3), 227-230.
