Effect of lipid-lowering activity of the natural original enzyme preparation in the experiment

   
Klyueva N.N.1 , Okunevich I.V.1, Parfenova N.S.1, Belova E.V.1, Ageeva E.V.1

1. Institute of Experimental Medicine, Saint-Petersburg, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20196503227      PubMed Id: 31258146
Year: 2019  Volume: 65  Issue: 3  Pages: 227-230
The experimental study in vivo was aimed at evaluation of hypolipidemic action of the original natural microbial enzyme preparation of cholesterol oxidase (CHO). In preliminary chronic experiments in rats, rabbits, dogs, low toxicity, good tolerability, and anti-atherosclerotic activity of the CHO preparation were established. To assess the effect of CHO under conditions of moderate, nutritional, atherogenic dyslipoproteinemia, experiments were carried out in rats, guinea pigs, and rabbits. It was shown that administration of CHO had the pronounced lipid-lowering effect in models of atherogenic dyslipoproteinemia induced in these animals.
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Keywords: cholesterol, atherosclerosis, lipoproteins, dyslipoproteinemia, cholesterol oxidase
Citation:

Klyueva, N. N., Okunevich, I. V., Parfenova, N. S., Belova, E. V., Ageeva, E. V. (2019). Effect of lipid-lowering activity of the natural original enzyme preparation in the experiment. Biomeditsinskaya khimiya, 65(3), 227-230.
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