The imbalance of vasoactive components and arachidonic acid in the placenta and amniotic fluid in preeclampsia

   
Pogorelova T.N.1 , Krukier I.I.1, Gunko V.O.1, Nikashina A.A.1, Alliluev I.A.2, Larichkin A.V.1

1. Scientific-Research Institute of Obstetrics and Pediatrics of Rostov State Medical University, Rostov-on-Don, Russia
2. Scientific-Research Institute of Obstetrics and Pediatrics of Rostov State Medical University, Rostov-on-Don, Russia; Academy of Biology and Biotechnology of the South Federal University, Rostov-on-Don, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20196503245      PubMed Id: 31258149
Year: 2019  Volume: 65  Issue: 3  Pages: 245-250
The content of vasoactive compounds and arachidonic acid in the placenta and amniotic fluid was studied in full-term (39-40 weeks) physiological pregnancy and preeclampsia (PE). The content of metabolites of nitric oxide (NOx), endothelin-1, thromboxane B2 (TxB2), prostacycline (PGI2) and arachidonic acid was estimated using spectrophotometric, immunoenzyme methods and gas-liquid chromatography. It was found that in PE the content of vasoconstrictors, of endothelin and TxB2, increased in the placenta and amniotic fluid, while the content of vasodilators, PGI2 and NOx decreased. Despite the same directionality of changes in both studied objects, the degree of changes differed and was more pronounced in the placenta. A direct or inverse correlative relationship was found between various vasoactive components (depending on their effect on vascular tone). In the case of arachidonic acid changes in its content in PE correlated with the level of vasoactive compounds, the source of which it is. The revealed differences in the ratio of vasoactive components obviously play a pathogenetic role in the development of PE and its subsequent complications.
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Keywords: vasoactive components, arachidonic acid, placenta, amniotic fluid, preeclampsia
Citation:

Pogorelova, T. N., Krukier, I. I., Gunko, V. O., Nikashina, A. A., Alliluev, I. A., Larichkin, A. V. (2019). The imbalance of vasoactive components and arachidonic acid in the placenta and amniotic fluid in preeclampsia. Biomeditsinskaya khimiya, 65(3), 245-250.
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