Hypercorticism during streptozotocin diabetes and mifepristone administration: the role of cyclic adenosine monophosphate

   
Selyatitskaya V.G.1 , Afonnikova E.D.1, Pal`chikova N.A.1, Kuz`minova O.I.1

1. Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20196504311      PubMed Id: 31436172
Year: 2019  Volume: 65  Issue: 4  Pages: 311-315
It was studed basal and ACTH-stimulated production of cyclic adenosine monophosphate (cAMP) and corticosteroid hormones (progesterone and corticosterone) in rat adrenals in vitro under streptozotocin diabetes, in conditions of mifepristone administration and their combination. It was shown that in streptozotocin diabetes animals, both the basal and adrenocorticotropic hormone (ACTH) stimulated cAMP production significantly increased; this was accompanied by the increase in basal and ACTH-stimulated progesterone and corticosterone production in rat adrenals in vitro. Repeated administration of mifepristone to control and diabetic rats caused an increase mainly in ACTH-stimulated production of the main glucocorticoid hormone, corticosterone, without additional changes in the cAMP level. The results obtained suggest activation of two mechanisms of steroidogenesis enhancement in experimental animals. In rats with streptozotocin diabetes, both basal and ACTH-stimulated activity of all stages of steroidogenesis increase, which is mediated by the increased formation of cAMP as second messenger mediating the ACTH action on adrenocortical cells. Prolonged administration of mifepristone to control and diabetic rats resulted in increased activity of only late stages of steroidogenesis with predominant elevation of synthesis of physiologically active hormone corticosterone without additional changes in cAMP production level.
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Keywords: streptozotocin diabetes, mifepristone, adrenocorticotropic hormone, cyclic adenosine monophosphate, progesterone, corticosterone
Citation:

Selyatitskaya, V. G., Afonnikova, E. D., Pal`chikova, N. A., Kuz`minova, O. I. (2019). Hypercorticism during streptozotocin diabetes and mifepristone administration: the role of cyclic adenosine monophosphate. Biomeditsinskaya khimiya, 65(4), 311-315.
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