1. Institute of Experimental Medicine, St. Petersburg, Russia; St. Petersburg State Medical Pediatric University, St. Petersburg, Russia 2. St. Petersburg State University, St. Petersburg, Russia 3. Institute of Experimental Medicine, St. Petersburg, Russia 4. Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia
The effects of acute (single) and chronic ethanol administration on the level of pro-inflammatory cytokines (IL-1β and TNF-α), as well as on the level of mRNA NF-κB, TLR4 and its endogenous agonist, HMGB1 protein, were investigated in rats. It was shown that the level of TLR4, HMGB1 and cytokines was significantly higher than in control group. The ethanol withdrawal after prolonged administration resulted in dysregulation of cytokine levels, TLR4 and HMGB1. Changes in the level of TLR4 and HMGB1 mRNA demonstrated a similar pattern. The obtained data confirm that prolonged alcoholization leads to the activation of TLR4-dependent signaling in the prefrontal cortex of rats, and this can lead to a prolonged neuro-inflammatory process in the brain.
Airapetov M.I., Eresko S.O., Lebedev A.A., Bychkov E.R., Shabanov P.D. (2019) Alcoholization and ethanol withdrawal leads to the activation of neuroimmune response in the prefrontal rat brain. Biomeditsinskaya Khimiya, 65(5), 380-384.
Airapetov M.I. et al. Alcoholization and ethanol withdrawal leads to the activation of neuroimmune response in the prefrontal rat brain // Biomeditsinskaya Khimiya. - 2019. - V. 65. -N 5. - P. 380-384.
Airapetov M.I. et al., "Alcoholization and ethanol withdrawal leads to the activation of neuroimmune response in the prefrontal rat brain." Biomeditsinskaya Khimiya 65.5 (2019): 380-384.
Airapetov, M. I., Eresko, S. O., Lebedev, A. A., Bychkov, E. R., Shabanov, P. D. (2019). Alcoholization and ethanol withdrawal leads to the activation of neuroimmune response in the prefrontal rat brain. Biomeditsinskaya Khimiya, 65(5), 380-384.
Airapetov M.I., Sexte E.A., Khokhlov P.P. et al. (2013) Narcology, 9, 61-65. Scholar google search
Airapetov M.I., Khokhlov P.P., Bychkov E.R. et al. (2015) Reviews in Clinical Pharmacology and Drug Therapy, 13(2), 10-13. CrossRef Scholar google search
Anokhina I.P. (2002) Basic biological mechanisms of alcohol and drug addiction, Medpraktika, Moscow. Scholar google search
Shabanov P.D., Lebedev A.A., Meshcherov Sh.K. (2002) Dopamine and brain support systems, Lan’, St. Petersburg. Scholar google search
Shabanov P.D., Lebedev A.A., Sexte E.A., Ayrapetov M.I., Eresko S.O., Khokhlov P.P., Bychkov E.R. (2017) Materials of the XXIII Congress of the Physiological Society named after I.P. Pavlov with international participation, pp. 2530-2532. Scholar google search
Antón M., Rodríguez-González A., Rodríguez-Rojo I.C., Pastor A., Correas Á., Serrano A., Orio L. (2017) Addiction Biology, 23(6), 1242-1250. CrossRef Scholar google search
Das N., Dewan V., Grace P.M., Gunn R.J., Tamura R., Tzarum N., Watkins L.R., Wilson I.A., Yin H. (2016) Cell Reports, 17, 1128-1140. CrossRef Scholar google search
Gong G., Yuan L.B., Hu L., Wu W., Yin L., Hou J.L., Liu Y.H., Zhou L.S. (2012) Acta Pharmacol., 33, 11-18. CrossRef Scholar google search
Montesinos J., Pascual M., Pla A., Maldonado C., Rodriguez-Arias M., Minarro J., Guerri C. (2015) Brain Behav. Immun., 45, 233-244. CrossRef Scholar google search
Breese G.R., Knapp D.J., Overstreet D.H., Navarro M., Wills T.A., Angel R.A. (2008) Neuropsychopharmacology, 33, 867-876. CrossRef Scholar google search
Alfonso-Loeches S., Pascual-Lucas M., Blanco A.M., Sanchez-Vera I., Guerri C. (2010) J. Neuroscience, 30(24), 8285-8295. CrossRef Scholar google search
