Alcoholization and ethanol withdrawal leads to the activation of neuroimmune response in the prefrontal rat brain

   
Airapetov M.I.1 , Eresko S.O.2, Lebedev A.A.3, Bychkov E.R.3, Shabanov P.D.4

1. Institute of Experimental Medicine, St. Petersburg, Russia; St. Petersburg State Medical Pediatric University, St. Petersburg, Russia
2. St. Petersburg State University, St. Petersburg, Russia
3. Institute of Experimental Medicine, St. Petersburg, Russia
4. Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20196505380      PubMed Id: 31666409
Year: 2019  Volume: 65  Issue: 5  Pages: 380-384
The effects of acute (single) and chronic ethanol administration on the level of pro-inflammatory cytokines (IL-1β and TNF-α), as well as on the level of mRNA NF-κB, TLR4 and its endogenous agonist, HMGB1 protein, were investigated in rats. It was shown that the level of TLR4, HMGB1 and cytokines was significantly higher than in control group. The ethanol withdrawal after prolonged administration resulted in dysregulation of cytokine levels, TLR4 and HMGB1. Changes in the level of TLR4 and HMGB1 mRNA demonstrated a similar pattern. The obtained data confirm that prolonged alcoholization leads to the activation of TLR4-dependent signaling in the prefrontal cortex of rats, and this can lead to a prolonged neuro-inflammatory process in the brain.
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Keywords: alcoholism, ethanol withdrawal, neuroinflammation, cytokines, TLR4, HMGB1
Citation:

Airapetov, M. I., Eresko, S. O., Lebedev, A. A., Bychkov, E. R., Shabanov, P. D. (2019). Alcoholization and ethanol withdrawal leads to the activation of neuroimmune response in the prefrontal rat brain. Biomeditsinskaya khimiya, 65(5), 380-384.
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