1. Institute of Experimental Medicine, St. Petersburg, Russia; St. Petersburg State Medical Pediatric University, St. Petersburg, Russia 2. University ITMO, St. Petersburg, Russia 3. Institute of Experimental Medicine, St. Petersburg, Russia 4. Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia
The neurotransmitter systems of the brain are exposed to dysregulation during alcohol withdrawal. This contributes to the development of the pathological craving for alcohol in which corticotropin-releasing hormone receptors are may be involved. During the period of alcohol withdrawal, the level of CRFR2 mRNA in the ventral tegmental area of the brain on the seventh day of abstinence was significantly increased in comparison with the control group. This supports existing concepts on possible participation in the modulation of dopaminergic and GABA-neural neurons in the ventral tegmental area the brain.
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Keywords: prolonged alcoholism, alcohol withdrawal, receptors of corticoliberin, CRFR2
Citation:
Airapetov M.I., Eresko S.O., Sekste E.A., Lebedev A.A., Bychkov E.R., Shabanov P.D. (2019) Ethanol withdrawal leads to an increase in the CRFR2 mRNA level in the ventricular tegmental region of the rat brain. Biomeditsinskaya Khimiya, 65(5), 385-387.
Airapetov M.I. et al. Ethanol withdrawal leads to an increase in the CRFR2 mRNA level in the ventricular tegmental region of the rat brain // Biomeditsinskaya Khimiya. - 2019. - V. 65. -N 5. - P. 385-387.
Airapetov M.I. et al., "Ethanol withdrawal leads to an increase in the CRFR2 mRNA level in the ventricular tegmental region of the rat brain." Biomeditsinskaya Khimiya 65.5 (2019): 385-387.
Airapetov, M. I., Eresko, S. O., Sekste, E. A., Lebedev, A. A., Bychkov, E. R., Shabanov, P. D. (2019). Ethanol withdrawal leads to an increase in the CRFR2 mRNA level in the ventricular tegmental region of the rat brain. Biomeditsinskaya Khimiya, 65(5), 385-387.
