Ethanol withdrawal leads to an increase in the CRFR2 mRNA level in the ventricular tegmental region of the rat brain

   
Airapetov M.I.1 , Eresko S.O.2, Sekste E.A.3, Lebedev A.A.3, Bychkov E.R.3, Shabanov P.D.4

1. Institute of Experimental Medicine, St. Petersburg, Russia; St. Petersburg State Medical Pediatric University, St. Petersburg, Russia
2. University ITMO, St. Petersburg, Russia
3. Institute of Experimental Medicine, St. Petersburg, Russia
4. Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20196505385      PubMed Id: 31666410
Year: 2019  Volume: 65  Issue: 5  Pages: 385-387
The neurotransmitter systems of the brain are exposed to dysregulation during alcohol withdrawal. This contributes to the development of the pathological craving for alcohol in which corticotropin-releasing hormone receptors are may be involved. During the period of alcohol withdrawal, the level of CRFR2 mRNA in the ventral tegmental area of the brain on the seventh day of abstinence was significantly increased in comparison with the control group. This supports existing concepts on possible participation in the modulation of dopaminergic and GABA-neural neurons in the ventral tegmental area the brain.
Download PDF:
Keywords: prolonged alcoholism, alcohol withdrawal, receptors of corticoliberin, CRFR2
Citation:

Airapetov, M. I., Eresko, S. O., Sekste, E. A., Lebedev, A. A., Bychkov, E. R., Shabanov, P. D. (2019). Ethanol withdrawal leads to an increase in the CRFR2 mRNA level in the ventricular tegmental region of the rat brain. Biomeditsinskaya khimiya, 65(5), 385-387.
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)