1. Institute of Experimental Medicine, St. Petersburg, Russia; St Petersburg University, St. Petersburg, Russia 2. Institute of Experimental Medicine, St. Petersburg, Russia 3. Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia
An imidazole derivative cramizol, has lipid-lowering and anti-atherogenic effects. Cramizol reduces blood levels of cholesterol and triglycerides, and also reduces the atherogenic index in animals with acute hyperlipidemia induced by Triton WR-1339. Cramizol and the lipid-lowering drug fenofibrate exhibited similar effectiveness as hypolipidemic agents. Cramizol also restores the expression of the Apoa1 gene in rats with experimentally induced hyperlipidemia to normal values. This may be a basis of its hypolipidemic and anti-atherogenic action.
Lizunov A.V., Okunevich I.V., Orlov S.V., Lebedev A.A., Bychkov E.R., Piotrovskiy L.B., Shabanov P.D. (2019) Effects of сramizol on expression of the ApoA1 gene in rats with experimental hyperlipidemia. Biomeditsinskaya Khimiya, 65(5), 403-406.
Lizunov A.V. et al. Effects of сramizol on expression of the ApoA1 gene in rats with experimental hyperlipidemia // Biomeditsinskaya Khimiya. - 2019. - V. 65. -N 5. - P. 403-406.
Lizunov A.V. et al., "Effects of сramizol on expression of the ApoA1 gene in rats with experimental hyperlipidemia." Biomeditsinskaya Khimiya 65.5 (2019): 403-406.
Lizunov, A. V., Okunevich, I. V., Orlov, S. V., Lebedev, A. A., Bychkov, E. R., Piotrovskiy, L. B., Shabanov, P. D. (2019). Effects of сramizol on expression of the ApoA1 gene in rats with experimental hyperlipidemia. Biomeditsinskaya Khimiya, 65(5), 403-406.
Abe C., Ikeda S., Uchida T., Yamashita K., Ichikawa T. (2007) J. Nutrition Nutrient Physiology, Metabolism, and Nutrient - Nutrient Interactions, 137, 345-350. Scholar google search
Vandesompele J., De Preter K., Pattyn F., Poppe B., van Roy N., de Paepe A., Speleman F. (2002) Genome Biology, 3(7), 0034.1-0034.11. CrossRef Scholar google search
