there any association of metabolic disturbances with joint destruction and pain?

   
Chetina E.V.1 , Markova G.A.1, Sharapova E.P.1

1. Nasonova Research Institute of Rheumatology, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20196506441      PubMed Id: 31876515
Year: 2019  Volume: 65  Issue: 6  Pages: 441-456
Osteoarthritis and type 2 diabetes mellitus represent two the most common chronic diseases. They possess many shared epidemiologic traits, have common risk factors, and embody heterogeneous multifactorial pathologies, which develop due to interaction of genetic an environmental factors. In addition, these diseases are often occurring in the same patient. In spite of the differences in clinical manifestation both diseases have similar disturbances of cellular metabolism, primarily associated with ATP production and utilization. The review discusses molecular mechanisms determining pathophysiological processes associated with glucose and lipid metabolism as well as the means aiming to alleviate the disturbances of energy metabolism as a new a therapeutic approach.
Download PDF:
Keywords: osteoarthritis, diabetes mellitus, glucose and lipid metabolism, joint destruction, pain
Citation:

Chetina, E. V., Markova, G. A., Sharapova, E. P. (2019). there any association of metabolic disturbances with joint destruction and pain?. Biomeditsinskaya khimiya, 65(6), 441-456.
References  
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)