Exosomes of malignant tumors: prospects of omiсs diagnostics

Shushkova N.A.1 , Novikova S.E.1, Zgoda V.G.1

1. Institute of Biomedical Chemistry, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20196506457      PubMed Id: 31876516
Year: 2019  Volume: 65  Issue: 6  Pages: 457-467
The main problems in the diagnostics and treatment of malignant tumors are early detection of the disease, prediction of the course of the disease and response to therapy. The solution may be associated with identification of biomarkers secreted by tumor cells within extracellular vesicles, known as exosomes. The study of exosome proteins attracts special attention, because their molecular composition can have information about tumor identity, and also represent a set of signaling molecules that regulate the processes of tumor progression and growth. In addition, the analysis of exosomes secreted into the extracellular space corresponds to the promising concept of a liquid biopsy. In this review, we have summarized the current experience in the molecular study of exosomes in various types of malignant tumors, including colorectal cancer, lung cancer, ovaries, prostate and breast cancer, with special emphasis on omics methods and outlined the prospects for their use in diagnosis.
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Keywords: exosomes, omics diagnostics, proteomics, transcriptomics, malignant tumors

Shushkova, N. A., Novikova, S. E., Zgoda, V. G. (2019). Exosomes of malignant tumors: prospects of omiсs diagnostics. Biomeditsinskaya Khimiya, 65(6), 457-467.
This paper is also available as the English translation: 10.1134/S1990750820020122
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