Study of stability of proline-containing derivatives of dopamine and serotonin in the biological media in vitro experiments

   
Shevchenko K.V.1 , Andreeva L.A.1, Nagaev I.Yu.1, Shevchenko V.P.1, Myasoedov N.F.1

1. Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20196506498      PubMed Id: 31876520
Year: 2019  Volume: 65  Issue: 6  Pages: 498-506
Boc-Gly-Pro-DP, Z-Gly-Pro-DP, LA-Gly-Pro-DP, Boc-Gly-Pro-Srt, Z-Gly-Pro-Srt were synthesized for the first time. The stability of these compounds in the presence of leucine aminopeptidase, carboxypeptidase Y, carboxypeptidase B and proline endopeptidase (PEP) was determined. It turned out that the compounds are stable in the presence of aminopeptidases and carboxypeptidases. In the presence of PEP, dopamine (DP) and serotonin (Srt) are cleaved from the synthesized preparations. Thus, new proline-containing Srt and DP derivatives were obtained, Srt and DP could be gradually released from them. This suggest the possibility of a prolonged action of these biologically active compounds on the vital activity of cells and, consequently, of the whole organism.
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Keywords: proline-containing dopamine and serotonin derivatives, peptide degradation, leucine aminopeptidase, carboxypeptidase, proline endopeptidase (PEP), blood plasma enzymes
Citation:

Shevchenko, K. V., Andreeva, L. A., Nagaev, I. Yu., Shevchenko, V. P., Myasoedov, N. F. (2019). Study of stability of proline-containing derivatives of dopamine and serotonin in the biological media in vitro experiments. Biomeditsinskaya khimiya, 65(6), 498-506.
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