Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus

   
Reikhardt B.A.1 , Shabanov P.D.1

1. Institute of Experimental Medicine, St. Petersburg, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20206602130     
Year: 2020  Volume: 66  Issue: 2  Pages: 130-137
Protein kinase CK2 is an important enzyme in the nervous system. The nuclear forms of CK2 regulate chromatin structure and gene expression, the key processes for long-term memory formation. Memory modulators, the Structural Analogues of Etimizole (SAE), were able to increase or decrease the activity of chromatin-associated CK in the cortex and hippocampus of rat brain in vitro. In vivo memory enhancers from SAE-group (3 mg/kg) stimulated CK2 activity and the transcriptional ability of chromatin in the cortex and hippocampus, starting from 30 min with a peak for 60 min and a duration up to 180 min. At these periods the memory inhibitor from the SAE-group reduced CK2 activity and chromatin transcription. It is assumed that the modulating effect of SAE on CK2 activity and transcription underlies the effects of these compounds on long-term memory.
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Keywords: brain, long-term memory, chromatin, transcription, protein phosphorylation, protein kinase CK2
Citation:

Reikhardt, B. A., Shabanov, P. D. (2020). Effect of etimizole structural analogues on protein kinase CK2, protein phosphorylation and transcription of chromatin in rat brain cortex and hippocampus. Biomeditsinskaya khimiya, 66(2), 130-137.
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