Neuroprotective mechanisms of the ubiquinol action in experimental focal ischemia

   
Fedorova T.N.1 , Gusakov V.S.2, Devyatov A.A.3, Muzichuk O.A.1, Lopachev A.V.1, Belousova M.A.2, Stvolinskii S.L.1, Povarova O.V.2, Gulyaev M.V.2, Medvedev O.S.2, Tutelyan V.A.4

1. Research Center of Neurology, Moscow, Russia
2. Lomonosov Moscow State University, Moscow, Russia
3. Research Center of Neurology, Moscow, Russia; Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia
4. Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20206602145     
Year: 2020  Volume: 66  Issue: 2  Pages: 145-150
Ischemic stroke is one of the most socially important diseases characterized by impaired cerebral circulation with focal damage of the brain tissue and decreased functionality. Despite the successes of modern pharmacology, possibilities of pharmacotherapy for stroke remain limited, and the research for new drugs with neuroprotective effects that can prevent brain cell death is still relevant. In this study we have investigated the neuroprotective activity of ubiquinol as a part of an innovative form on a rat model of irreversible 24 h-cerebral ischemia with evaluation of the mechanisms of its neuroprotective effect. Ubiquinol (30 mg/kg), administered intravenously in the acute period of irreversible 24 h focal cerebral ischemia, had a direct neuroprotective effect, characterized by a decrease in the volume of brain tissue necrosis. The protective effect of ubiquinol is due to its ability to inhibit the development of oxidative stress by the direct anti-radical action, preventing the increase in the lipid hydroperoxide content in the brain tissue adjacent to the focus of necrosis, lowering the lipid oxidation rate in plasma against under conditions of increased total antioxidant activity in the brain and blood of experimental animals. In vitro experiments have shown the ability of ubiquinol to prevent cell death in primary culture of cerebral neurons of rat brain under 4 h oxygen/glucose deprivation followed by 20 h reoxygenation.
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Keywords: focal cerebral ischemia, neuroprotection, antioxidants, ubiquinol
Citation:

Fedorova, T. N., Gusakov, V. S., Devyatov, A. A., Muzichuk, O. A., Lopachev, A. V., Belousova, M. A., Stvolinskii, S. L., Povarova, O. V., Gulyaev, M. V., Medvedev, O. S., Tutelyan, V. A. (2020). Neuroprotective mechanisms of the ubiquinol action in experimental focal ischemia. Biomeditsinskaya khimiya, 66(2), 145-150.
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