Autoimmune markers for non-invasive diagnosis of endometriosis in women

   
Menzhinskaya I.V.1 , Melkumyan A.G.1, Pavlovich S.V.1, Chuprynin V.D.1, Vanko L.V.1, Sukhikh G.T.1

1. Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20206602162     
Year: 2020  Volume: 66  Issue: 2  Pages: 162-166
Endometriosis is a common estrogen-dependent chronic disease in women of reproductive age; it is associated with dysregulation of the immune response, local inflammation, and increased formation of autoantibodies. The aim of the study was to investigate the profile of autoantibodies in women with endometriosis and to evaluate their diagnostic value using new modifications of enzyme immunoassay. In women with endometriosis of stage III-IV (n=39), a wide spectrum of autoantibodies was detected, mainly of class G, including antibodies to endometrial antigens (tropomyosin 3, tropomodulin 3), the enzyme α-enolase, steroid (estradiol, progesterone) and gonadotropic hormones. At the same time, the frequency of detection of IgG antibodies to tropomyosin 3, α-enolase, estradiol and human chorionic gonadotropin and their levels in patients with endometriosis were higher than in healthy women (n=26) (p<0.05). IgG-antibodies to tropomyosin 3, α-enolase and estradiol were characterized by higher diagnostic value for endometriosis. The diagnostic value was significantly increased when these antibodies were combined: the AUC reached 0.875 [0.772-0.978] (p<0.0001), the sensitivity and specificity were 83.3% each. Thus, autoantibodies to tropomyosin 3, α-enolase, and estradiol are promising for inclusion in the panel of biomarkers for non-invasive diagnosis of endometriosis.
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Keywords: endometriosis, non-invasive diagnostics, autoantibodies to tropomyosin 3, α-enolase, estradiol
Citation:

Menzhinskaya, I. V., Melkumyan, A. G., Pavlovich, S. V., Chuprynin, V. D., Vanko, L. V., Sukhikh, G. T. (2020). Autoimmune markers for non-invasive diagnosis of endometriosis in women. Biomeditsinskaya khimiya, 66(2), 162-166.
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