Autoimmune markers for non-invasive diagnosis of endometriosis in women

Menzhinskaya I.V.1 , Melkumyan A.G.1, Pavlovich S.V.1, Chuprynin V.D.1, Vanko L.V.1, Sukhikh G.T.1

1. Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20206602162      PubMed Id: 32420898
Year: 2020  Volume: 66  Issue: 2  Pages: 162-166
Endometriosis is a common estrogen-dependent chronic disease in women of reproductive age; it is associated with dysregulation of the immune response, local inflammation, and increased formation of autoantibodies. The aim of the study was to investigate the profile of autoantibodies in women with endometriosis and to evaluate their diagnostic value using new modifications of enzyme immunoassay. In women with endometriosis of stage III-IV (n=39), a wide spectrum of autoantibodies was detected, mainly of class G, including antibodies to endometrial antigens (tropomyosin 3, tropomodulin 3), the enzyme α-enolase, steroid (estradiol, progesterone) and gonadotropic hormones. At the same time, the frequency of detection of IgG antibodies to tropomyosin 3, α-enolase, estradiol and human chorionic gonadotropin and their levels in patients with endometriosis were higher than in healthy women (n=26) (p<0.05). IgG-antibodies to tropomyosin 3, α-enolase and estradiol were characterized by higher diagnostic value for endometriosis. The diagnostic value was significantly increased when these antibodies were combined: the AUC reached 0.875 [0.772-0.978] (p<0.0001), the sensitivity and specificity were 83.3% each. Thus, autoantibodies to tropomyosin 3, α-enolase, and estradiol are promising for inclusion in the panel of biomarkers for non-invasive diagnosis of endometriosis.
Download PDF:  
Keywords: endometriosis, non-invasive diagnostics, autoantibodies to tropomyosin 3, α-enolase, estradiol

Menzhinskaya, I. V., Melkumyan, A. G., Pavlovich, S. V., Chuprynin, V. D., Vanko, L. V., Sukhikh, G. T. (2020). Autoimmune markers for non-invasive diagnosis of endometriosis in women. Biomeditsinskaya Khimiya, 66(2), 162-166.
This paper is also available as the English translation: 10.1134/S1990750820040083
 2024 (vol 70)
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)