Analysis of metabolic pathways in intrauterine growth restriction

Kan N.E.1, Khachatryan Z.V.1 , Chagovets V.V.1, Starodubtseva N.L.1, Amiraslanov E.Yu.1, Tyutyunnik V.L.1, Lomova N.A.1, Frankevich V.E.1

1. Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
Section: Clinical and Diagnostic Research
DOI: 10.18097/PBMC20206602174     
Year: 2020  Volume: 66  Issue: 2  Pages: 174-180
Objective was to analyze metabolic pathways based on a study of the metabolomic profile of pregnant women with intrauterine growth restriction. The metabolic profile of pregnant women with fetal growth restriction has been analyzed using liquid chromatography-mass spectrometry. At the second stage pathways were identified using SMPDB and MetaboAnalyst databases to clarify the relationship between metabolites. Biological networks allow to determine the effect of proteins on the metabolic pathways involved in pathogenesis of IUGR and determine the epigenetic mechanisms of its formation.
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Keywords: intrauterine growth restriction, metabolomics, amino acids, metabolic pathways, biological network

Kan, N. E., Khachatryan, Z. V., Chagovets, V. V., Starodubtseva, N. L., Amiraslanov, E. Yu., Tyutyunnik, V. L., Lomova, N. A., Frankevich, V. E. (2020). Analysis of metabolic pathways in intrauterine growth restriction. Biomeditsinskaya Khimiya, 66(2), 174-180.
This paper is also available as the English translation: 10.1134/S1990750820040071
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