Blood metabolome analysis for creating a digital image of a healthy person

Trifonova O.P.1 , Balashova E.E.1, Maslov D.L.1, Grigoriev A.I.2, Lisitsa A.V.1, Ponomarenko E.A.1, Archakov A.I.1

1. Institute of Biomedical Chemistry, Moscow, Russia
2. Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20206603216      PubMed Id: 32588827
Year: 2020  Volume: 66  Issue: 3  Pages: 216-223
In the frame of the work, data on the implementation of metabolomics tests in medicine have been systematized. Based on the obtained data, a set of protocols was proposed, the sequential realization of which makes it possible to conduct a blood metabolome analysis for medical purposes. Using this analysis and the number of blood samples from healthy volunteers, a prototype of a healthy person's metabolomic image has been developed; it allows visually and digitally to assess the compliance of the human blood metabolome with the norm. At the same time, 99% of the metabolic processes reflected in the blood plasma are estimated. If abnormalities are detected, the metabolomic image allows to get the value of these deviations of metabolic processes in digital terms.
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Keywords: metabolomics, precision medicine, laboratory diagnostics, blood metabolome, direct injection mass spectrometry, digital image of a person

Trifonova, O. P., Balashova, E. E., Maslov, D. L., Grigoriev, A. I., Lisitsa, A. V., Ponomarenko, E. A., Archakov, A. I. (2020). Blood metabolome analysis for creating a digital image of a healthy person. Biomeditsinskaya Khimiya, 66(3), 216-223.
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