The role of lipids in the classification of astrocytoma and glioblastoma using MS tumor profiling

   
Eliferov V.A.1, Zhvansky E.S.1, Sorokin A.A.1, Shurkhay V.A.2, Bormotov D.S.1, Pekov S.I.1, Nikitin P.V.2, Ryzhova M.V.2, Kulikov E.E.3, Potapov A.A.2, Nikolaev E.N.4, Popov I.A.1

1. Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Russia
2. N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia
3. Moscow Institute of Physics and Technology (National Research University), Dolgoprudny, Russia; Federal Research Center “Fundamentals of Biotechnology”, RAS, Moscow, Russia
4. Skolkovo Institute of Science and Technology, Moscow, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20206604317      PubMed Id: 32893821
Year: 2020  Volume: 66  Issue: 4  Pages: 317-325
Express MS identification of biological tissues has become a much more accessible research method due to the application of direct specimen ionization at atmospheric pressure. In contrast to traditional methods of analysis employing GC-MS methods for determining the molecular composition of the analyzed objects it eliminates the influence of mutual ion suppression. Despite significant progress in the field of direct MS of biological tissues, the question of mass spectrometric profile attribution to a certain type of tissue still remains open. The use of modern machine learning methods and protocols (e.g., “random forests”) enables us to trace possible relationships between the components of the sample MS profile and the result of brain tumor tissue classification (astrocytoma or glioblastoma). It has been shown that the most pronounced differences in the mass spectrometric profiles of these tumors are due to their lipid composition. Detection of statistically significant differences in lipid profiles of astrocytoma and glioblastoma may be used to perform an express test during surgery and inform the neurosurgeon what type of malignant tissue he is working with. The ability to accurately determine the boundaries of the neoplastic growth significantly improves the quality of both surgical intervention and postoperative rehabilitation, as well as the duration and quality of life of patients.
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Keywords: mass spectrometry, brain tumors, direct profiling, statistical data analysis
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Eliferov, V. A., Zhvansky, E. S., Sorokin, A. A., Shurkhay, V. A., Bormotov, D. S., Pekov, S. I., Nikitin, P. V., Ryzhova, M. V., Kulikov, E. E., Potapov, A. A., Nikolaev, E. N., Popov, I. A. (2020). The role of lipids in the classification of astrocytoma and glioblastoma using MS tumor profiling. Biomeditsinskaya khimiya, 66(4), 317-325.
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