Features of free radical processes in the liver of rats with a nutrient imbalance

   
Voloshchuk O.N.1 , Stus Yu.V.1, Kopylchuk G.P.1

1. Fedkovych Chernovtsi National University, Institute of Biology, Chemistry and Bioresources, Department of Biochemistry and Biotechnology, Chernovtsi, Ukraine
Section: Experimental Study
DOI: 10.18097/PBMC20206605386      PubMed Id: 33140732
Year: 2020  Volume: 66  Issue: 5  Pages: 386-391
The activity of free radical processes in liver mitochondria was investigated in rats kept on high-sucrose and low protein/high-sucrose diets. Excess of dietary sucrose caused intensification of free radical processes in liver mitochondria as evidenced by increased hydroxyl radical generation, accumulation of primary (conjugated dienes, ketodienes) and secondary products (TBA-reactive products) of lipid peroxidation, increased cholesterol/phospholipids ratio and also accumulation of oxidative modification products of proteins (carbonyl derivatives). Additional nutritional protein deficiency (low protein/high-sucrose diet) enhanced destructive changes in liver mitochondria. This suggests a critical role of nutrient protein supplementation for maintaining the functional activity of mitochondria. The established changes can be considered as one of possible mechanisms of functional liver activity violation in conditions of nutrient imbalance.
Download PDF:
Keywords: liver, hydroxyl radical, lipid peroxidation, protein oxidation, high-sucrose ration, low protein ration
Citation:

Voloshchuk, O. N., Stus, Yu. V., Kopylchuk, G. P. (2020). Features of free radical processes in the liver of rats with a nutrient imbalance. Biomeditsinskaya khimiya, 66(5), 386-391.
References  
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)