Ethanol induced increase of fibroblast growth factor 2 mRNA content in emotiogenic brain structures of rats

   
Airapetov M.I.1 , Eresco S.O.2, Lebedev A.A.3, Bychkov E.R.3, Shabanov P.D.4

1. Institute of Experimental Medicine, St. Petersburg, Russia; Saint-Petersburg State Pediatric Medical University, St. Petersburg, Russia
2. Saint-Petersburg State University, St. Petersburg, Russia
3. Institute of Experimental Medicine, St. Petersburg, Russia
4. Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia
Section: Short Communication
DOI: 10.18097/PBMC20206605419      PubMed Id: 33140737
Year: 2020  Volume: 66  Issue: 5  Pages: 419-422
We studied the effects of acute, subacute, and chronic alcohol treatment of rats on the content of fibroblast growth factor 2 (FGF2) mRNA in various brain structures. Results suggest a possible role of FGF2 in the functioning of dopaminergic neurons in the midbrain. In our experiment, ethanol treatment of rats was accompanied by an increase in the FGF2 mRNA level in the emotiogenic structures of the brain. This effect was blocked by pretreatment of animals with chlorpromazine. This suggests FGF2 involvement in the mechanisms of alcohol dependence and can be considered as a possible diagnostic and therapeutic target in alcoholism.
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Keywords: ethanol, alcoholism, FGF2, D2R, brain, rats
Citation:

Airapetov, M. I., Eresco, S. O., Lebedev, A. A., Bychkov, E. R., Shabanov, P. D. (2020). Ethanol induced increase of fibroblast growth factor 2 mRNA content in emotiogenic brain structures of rats. Biomeditsinskaya khimiya, 66(5), 419-422.
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