Comparative effect of the prolyl endopeptidase inhibitors, benzyloxycarbonyl-prolyl-prolinal and benzyloxycarbonyl-methionyl-cyanopyrrolidine, on the acute exudative inflammation and visceral pain in mice

   
Ivanova E.A.1 , Zolotov N.N.1, Voronina T.A.1

1. Zakusov Institute of Pharmacology, Moscow, Russia
Section: Short Communication
DOI: 10.18097/PBMC20206605423      PubMed Id: 33140738
Year: 2020  Volume: 66  Issue: 5  Pages: 423-426
A selective prolyl endopeptidase (PEP) inhibitor benzyloxycarbonyl-prolyl-prolinal (IC50 = 1,61±0,12 nmol/l) and a nonselective PEP inhibitor benzyloxycarbonyl-methionyl-cyanopyrrolidine (IC50 = 2,01±0,14 nmol/l) exhibit a comparable antiexudative effect at single doses of 2 mg/kg and 5 mg/kg (intraperitoneally) in outbred mice with peritonitis induced by 1% acetic acid. However, only benzyloxycarbonyl-methionyl-cyanopyrrolidine at a dose of 5 mg/kg reduces acetic acid induced pain in animals.
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Keywords: prolyl endopeptidase, benzyloxycarbonyl-prolyl-prolinal, benzyloxycarbonyl-methionyl-cyanopyrrolidine, acetic acid-induced peritonitis, visceral pain
Citation:

Ivanova, E. A., Zolotov, N. N., Voronina, T. A. (2020). Comparative effect of the prolyl endopeptidase inhibitors, benzyloxycarbonyl-prolyl-prolinal and benzyloxycarbonyl-methionyl-cyanopyrrolidine, on the acute exudative inflammation and visceral pain in mice. Biomeditsinskaya khimiya, 66(5), 423-426.
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