1. Institute of Toxicology, Saint-Petersburg, Russia; St. Petersburg State Pediatric Medical University, Saint-Petersburg, Russia 2. Institute of Toxicology, Saint-Petersburg, Russia
Ten biochemical parameters total protein, albumin, glucose, cholesterol, urea, creatinine, total bilirubin, ALT, AST, APh were determined during long-term light mode changes in serum of rats. Changing the light mode, a number of parameters revealed unreliable 24-hour rhythms. An ultradian 12-hour reliable rhythm has been for serum total protein of rats exposed to constant darkness during 1 month. The light-modified model can be used to study the effects of the chemical factor in combination with the physical factor of the external environment, as well as in preclinical toxicity tests of medicinal substances in different light modes.
Batotsyrenova E.G., Zolotoverkhaja E.A., Kashuro V.A., Sharabanov A.V. (2020) Changes of biochemical parameters in blood serum rats under chronic light desynchronosis. Biomeditsinskaya Khimiya, 66(6), 450-455.
Batotsyrenova E.G. et al. Changes of biochemical parameters in blood serum rats under chronic light desynchronosis // Biomeditsinskaya Khimiya. - 2020. - V. 66. -N 6. - P. 450-455.
Batotsyrenova E.G. et al., "Changes of biochemical parameters in blood serum rats under chronic light desynchronosis." Biomeditsinskaya Khimiya 66.6 (2020): 450-455.
Batotsyrenova, E. G., Zolotoverkhaja, E. A., Kashuro, V. A., Sharabanov, A. V. (2020). Changes of biochemical parameters in blood serum rats under chronic light desynchronosis. Biomeditsinskaya Khimiya, 66(6), 450-455.
References
Zeng L., Ming C., Li Y., Su L.Y., Su Y.H., Otecko N.O., Liu H.Q., Wang M.S., Yao Y.G., Li H.P., Wu D.D., Zhang Y.P. (2017) Molecul. Biol. Evol., 34(12), 3148-3153. CrossRef Scholar google search
Baevskii R.M., Breus T.K., Nikulina V.M., Chernikova A.G. (1998) Preprint IKI RAN, 1987, 37. Scholar google search
Deryapa N.R., Moshkin M.P., Posnyj V.S. (1989) Problemy medicinskoj bioritmologii – M., Medicina, p. 207. Scholar google search
Zaslavskaya R.M. (1994) Sutochnye ritmy svertyvayushchej sistemy krovi v norme i patologii i problemy terapii — M., “Kvartet”, p. 452. Scholar google search
Fateeva N.M., Kolesnik Yu.Yu., Kolpakov V.V. (1998) In.: Materialy USH Mezhdunarodnogo simpoziuma “Ekologo-fiziologicheskie problemy adaptacii”, — M., RUDN, 393-394. Scholar google search
