Changes of biochemical parameters in blood serum rats under chronic light desynchronosis

   
Batotsyrenova E.G.1 , Zolotoverkhaja E.A.2, Kashuro V.A.2, Sharabanov A.V.2

1. Institute of Toxicology, Saint-Petersburg, Russia; St. Petersburg State Pediatric Medical University, Saint-Petersburg, Russia
2. Institute of Toxicology, Saint-Petersburg, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20206606450      PubMed Id: 33372902
Year: 2020  Volume: 66  Issue: 6  Pages: 450-455
Ten biochemical parameters total protein, albumin, glucose, cholesterol, urea, creatinine, total bilirubin, ALT, AST, APh were determined during long-term light mode changes in serum of rats. Changing the light mode, a number of parameters revealed unreliable 24-hour rhythms. An ultradian 12-hour reliable rhythm has been for serum total protein of rats exposed to constant darkness during 1 month. The light-modified model can be used to study the effects of the chemical factor in combination with the physical factor of the external environment, as well as in preclinical toxicity tests of medicinal substances in different light modes.
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Keywords: modeling, desynchronosis, biorhythms, light mode, toxicity
Citation:

Batotsyrenova, E. G., Zolotoverkhaja, E. A., Kashuro, V. A., Sharabanov, A. V. (2020). Changes of biochemical parameters in blood serum rats under chronic light desynchronosis. Biomeditsinskaya khimiya, 66(6), 450-455.
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