The role of nociceptin in opioid regulation of brain functions

Shamakina I.Yu.1 , Shagiakhmetov F.Sh.2, Anokhin P.K.1, Kohan V.S.1, Davidova T.V.2

1. V.P. Serbsky National Medical Research Center on Psychiatry and Addiction, Moscow, Russia
2. The Institute of General Pathology and Pathophysiology, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20216701005      PubMed Id: 33645518
Year: 2021  Volume: 67  Issue: 1  Pages: 5-16
This review discusses our current knowledge on the nociceptin/orphanin (N/OFQ) system regarding its role in regulation of brain functions. Nociceptin receptor (NOPr) was identified in 1994 [Bunzow et al., 1994; Mollereau et al., 1994]. In 1995 a 17 amino acid endogenous peptide was found to be the high-affinity ligand for the NOPr [Reinscheid et al., 1995]. N/OFQ has a broad spectrum of activity and can act as on opioid-like as well as an anti-opioid peptide. Considering high level of N/OFQ and NOPr mRNA expression in the limbic brain regions, the N/OFQ/NOP system is suggested to be involved in regulation of emotions, resward, pain sensitivity, stress responsibility, sexual behavior, aggression, drug abuse and addiction. However it is still not well understood whether an increased vulnerability to drugs of abuse may be associated with dysregulation of N/OFQ/NOP system. Current review further highlights a need for further research on N/OFQ/NOP system as it could have clinical utility for substance abuse, depression, and anxiety pharmacotherapy.
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Keywords: brain, opioid peptides, nociceptin, stress, pain, addiction

Shamakina, I. Yu., Shagiakhmetov, F. Sh., Anokhin, P. K., Kohan, V. S., Davidova, T. V. (2021). The role of nociceptin in opioid regulation of brain functions. Biomeditsinskaya Khimiya, 67(1), 5-16.
This paper is also available as the English translation: 10.1134/S1990750821030094
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