1. Institute of Experimental Medicine, St. Petersburg, Russia; St. Petersburg State Medical Pediatric University, St. Petersburg, Russia 2. St. Petersburg State University, St. Petersburg, Russia 3. Institute of Experimental Medicine, St. Petersburg, Russia 4. Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia
Intracellular signaling mediated by the HMGB1 protein, an agonist of TLRs, is considered as a possible target for the correction of pathologies of the neuroimmune system, however, the expression level of the Hmgb1 gene has not been previously studied in various brain structures of rats exposed to prolonged alcoholization followed by ethanol withdrawal. The study showed that long-term use of ethanol caused to an increase in the level of Hmgb1 mRNA in the striatum of rat brain. Alcohol withdrawal changed the level Hmgb1 mRNA in the striatum and amygdala on the 1st and 14th day. The data obtained may indicate that in different structures of the brain there are multidirectional changes in the molecular mechanisms of the neuroimmune response with prolonged use of ethanol and its withdrawal.
Airapetov M.I., Eresko S.O., Bychkov E.R., Lebedev A.A., Shabanov P.D. (2021) HMGB1 gene expression changes in the striatum and amigdal of the rat's brain under alcoholization and ethanol withdrawal. Biomeditsinskaya Khimiya, 67(1), 95-99.
Airapetov M.I. et al. HMGB1 gene expression changes in the striatum and amigdal of the rat's brain under alcoholization and ethanol withdrawal // Biomeditsinskaya Khimiya. - 2021. - V. 67. -N 1. - P. 95-99.
Airapetov M.I. et al., "HMGB1 gene expression changes in the striatum and amigdal of the rat's brain under alcoholization and ethanol withdrawal." Biomeditsinskaya Khimiya 67.1 (2021): 95-99.
Airapetov, M. I., Eresko, S. O., Bychkov, E. R., Lebedev, A. A., Shabanov, P. D. (2021). HMGB1 gene expression changes in the striatum and amigdal of the rat's brain under alcoholization and ethanol withdrawal. Biomeditsinskaya Khimiya, 67(1), 95-99.
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