Ionotropic glutamate receptors of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype play a key role in synaptic plasticity representing one of the mechanisms for learning and memory formation. They can also serve as targets for the development of novel classes of pharmaceuticals for the treatment or substantive correction of many serious neurodegenerative and psychoneurological disorders. The search and studies of various types of AMPA receptor ligands attract considerable attention from academic organizations and pharmaceutical companies all over the world. This review mainly focuses on recent advances in this field. The architecture and operational mechanism of the receptor as well as its major binding sites and ligand types are considered. Special attention is paid to the studies of mechanisms of action and novel chemotypes of AMPA receptor agonists and competitive antagonists, positive and negative allosteric modulators, auxiliary protein-dependent allosteric modulators, and ion channel blockers.
Radchenko E.V., Tarakanova A.S., Karlov D.S., Lavrov M.I., Palyulin V.A. (2021) Ligands of the AMPA-subtype glutamate receptors: mechanisms of action and novel chemotypes. Biomeditsinskaya Khimiya, 67(3), 187-200.
Radchenko E.V. et al. Ligands of the AMPA-subtype glutamate receptors: mechanisms of action and novel chemotypes // Biomeditsinskaya Khimiya. - 2021. - V. 67. -N 3. - P. 187-200.
Radchenko E.V. et al., "Ligands of the AMPA-subtype glutamate receptors: mechanisms of action and novel chemotypes." Biomeditsinskaya Khimiya 67.3 (2021): 187-200.
Radchenko, E. V., Tarakanova, A. S., Karlov, D. S., Lavrov, M. I., Palyulin, V. A. (2021). Ligands of the AMPA-subtype glutamate receptors: mechanisms of action and novel chemotypes. Biomeditsinskaya Khimiya, 67(3), 187-200.
Lauterborn J.C., Palmer L.C., Jia Y., Pham D.T., Hou B., Wang W., Trieu B.H., Cox C.D., Kantorovich S., Gall C.M., Lynch G. (2016) J. Neurosci., 36(5), 1636-1646. CrossRef Scholar google search
Lee K., Goodman L., Fourie C., Schenk S., Leitch B., Montgomery J.M. (2016) in: Ion Channels as Therapeutic Targets, Part A (Donev R., ed.) Academic Press, pp. 203-261. CrossRef Scholar google search
Pirotte B., Francotte P., Goffin E., de Tullio P. (2013) Expert Opin. Ther. Pat., 23(5), 615-628. CrossRef Scholar google search
Carrillo E., Shaikh S.A., Berka V., Durham R.J., Litwin D.B., Lee G., MacLean D.M., Nowak L.M., Jayaraman V. (2020) J. Gen. Physiol., 152(1), e201912451. CrossRef Scholar google search
Cais O., Herguedas B., Krol K., Cull-Candy S.G., Farrant M., Greger I.H. (2014) Cell. Rep., 9(2), 728-740. CrossRef Scholar google search
Lee J.Y., Krieger J., Herguedas B., García-Nafría J., Dutta A., Shaikh S.A., Greger I.H., Bahar I. (2019) Structure, 27(2), 241-252. CrossRef Scholar google search
Barber D.M., Liu S.-A., Gottschling K., Sumser M., Hollmann M., Trauner D. (2017) Chem. Sci., 8(1), 611-615. CrossRef Scholar google search
Orain D., Tasdelen E., Haessig S., Koller M., Picard A., Dubois C., Lingenhoehl K., Desrayaud S., Floersheim P., Carcache D., Urwyler S., Kallen J., Mattes H. (2017) ChemMedChem, 12(3), 197-201. CrossRef Scholar google search
Szymańska E., Chałupnik P., Johansen T.N., Nielsen B., Cuñado Moral A.M., Pickering D.S., Więckowska A., Kieć-Kononowicz K. (2017) Chem. Biol. Drug. Des., 90(6), 1271-1281. CrossRef Scholar google search
Szymańska E., Nielsen B., Johansen T.N., Cuñado Moral A.M., Pickering D.S., Szczepańska K., Mickowska A., Kieć-Kononowicz K. (2017) Eur. J. Med. Chem., 138, 874-883. CrossRef Scholar google search
Drapier T., Geubelle P., Bouckaert C., Nielsen L., Laulumaa S., Goffin E., Dilly S., Francotte P., Hanson J., Pochet L., Kastrup J.S., Pirotte B. (2018) J. Med. Chem., 61(12), 5279-5291. CrossRef Scholar google search
Ward S.E., Beswick P., Calcinaghi N., Dawson L.A., Gartlon J., Graziani F., Jones D.N.C., Lacroix L., Selina Mok M.H., Oliosi B., Pardoe J., Starr K., Woolley M.L., Harries M.H. (2017) Br. J. Pharmacol., 174(5), 370-385. CrossRef Scholar google search
Ward S.E., Harries M.H., Aldegheri L., Bradford A.M., Ballini E., Dawson L., Lacroix L., Pardoe J., Starr K., Weil A., Waters K., Atack J.R., Woolley M. (2020) J. Psychopharmacol., 34(1), 93-102. CrossRef Scholar google search
Nakajima M., Suda S., Sowa K., Sakamoto Y., Nito C., Nishiyama Y., Aoki J., Ueda M., Yokobori S., Yamada M., Yokota H., Okada T., Kimura K. (2018) Neuroscience, 386, 256-264. CrossRef Scholar google search
Lange F., Weßlau K., Porath K., Hörnschemeyer J., Bergner C., Krause B.J., Mullins C.S., Linnebacher M., Köhling R., Kirschstein T. (2019) PLoS One, 14(2), e0211644. CrossRef Scholar google search
Nozawa A., Ozeki M., Matsuoka M., Nakama M., Yasue S., Endo S., Kawamoto N., Ohnishi H., Fukao T. (2019) Anticancer Res., 39(7), 3595-3599. CrossRef Scholar google search
Ribeiro M.P.C., Custódio J.B.A., Santos A.E. (2017) Cancer Chemother. Pharmacol., 79(2), 219-225. CrossRef Scholar google search
Yelshanskaya M.V., Singh A.K., Sampson J.M., Narangoda C., Kurnikova M., Sobolevsky A.I. (2016) Neuron, 91(6), 1305-1315. CrossRef Scholar google search
Espahbodinia M., Ettari R., Wen W., Wu A., Shen Y.-C., Niu L., Grasso S., Zappalà M. (2017) Bioorg. Med. Chem., 25(14), 3631-3637. CrossRef Scholar google search
Inami H., Shishikura J.-I., Yasunaga T., Hirano M., Kimura T., Yamashita H., Ohno K., Sakamoto S. (2019) Chem. Pharm. Bull. (Tokyo), 67(7), 699-706. CrossRef Scholar google search
Qneibi M., Hamed O., Fares O., Jaradat N., Natsheh A.-R., AbuHasan Q., Emwas N., Al-Kerm R., Al-Kerm R. (2019) Eur. J. Pharm. Sci., 136, 104951. CrossRef Scholar google search
Qneibi M., Hamed O., Natsheh A.-R., Fares O., Jaradat N., Emwas N., AbuHasan Q., Al-Kerm R., Al-Kerm R. (2019) PLoS One, 14(8), e0221132. CrossRef Scholar google search
Jaremko W.J., Huang Z., Wen W., Wu A., Karl N., Niu L. (2017) J. Biol. Chem., 292(18), 7338-7347. CrossRef Scholar google search
Jaremko W., Huang Z., Karl N., Pierce V.D., Lynch J., Niu L. (2020) J. Biol. Chem., 295(19), 6280-6288. CrossRef Scholar google search
Dohrke J.-N., Watson J.F., Birchall K., Greger I.H. (2020) J. Biol. Chem., 295(43), 14565-14577. CrossRef Scholar google search
Gardinier K.M., Gernert D.L., Porter W.J., Reel J.K., Ornstein P.L., Spinazze P., Stevens F.C., Hahn P., Hollinshead S.P., Mayhugh D., Schkeryantz J., Khilevich A., de Frutos O., Gleason S.D., Kato A.S., Luffer-Atlas D., Desai P.V., Swanson S., Burris K.D., Ding C., Heinz B.A., Need A.B., Barth V.N., Stephenson G.A., Diseroad B.A., Woods T.A., Yu H., Bredt D., Witkin J.M. (2016) J. Med. Chem., 59(10), 4753-4768. CrossRef Scholar google search
Maher M.P., Wu N., Ravula S., Ameriks M.K., Savall B.M., Liu C., Lord B., Wyatt R.M., Matta J.A., Dugovic C., Yun S., Ver Donck L., Steckler T., Wickenden A.D., Carruthers N.I., Lovenberg T.W. (2016) J. Pharmacol. Exp. Ther., 357(2), 394-414. CrossRef Scholar google search
Ravula S., Savall B.M., Wu N., Lord B., Coe K., Wang K., Seierstad M., Swanson D.M., Ziff J., Nguyen M., Leung P., Rynberg R., La D., Pippel D.J., Koudriakova T., Lovenberg T.W., Carruthers N.I., Maher M.P., Ameriks M.K. (2018) ACS Med. Chem. Lett., 9(8), 821-826. CrossRef Scholar google search
Savall B.M., Wu D., Swanson D.M., Seierstad M., Wu N., Vives Martinez J., García Olmos B., Lord B., Coe K., Koudriakova T., Lovenberg T.W., Carruthers N.I., Maher M.P., Ameriks M.K. (2019) ACS Med. Chem. Lett., 10(3), 267-272. CrossRef Scholar google search
Azumaya C.M., Days E.L., Vinson P.N., Stauffer S., Sulikowski G., Weaver C.D., Nakagawa T. (2017) PLoS One, 12(3), e0174742. CrossRef Scholar google search
