The TLR3 induction increases content of interferons in rat's brain by TRAIL signaling during long-term alcoholization

   
Airapetov M.I.1 , Eresko S.O.2, Vasilev A.K.3, Vasileva V.Y.3, Bychkov E.R.3, Lebedev A.A.3, Shabanov P.D.4

1. Institute of Experimental Medicine, St. Petersburg, Russia; Saint Petersburg State Pediatric Medical University, St. Petersburg, Russia
2. Institute of Experimental Medicine, St. Petersburg, Russia; Saint-Petersburg State Chemical and Pharmaceutical University, St. Petersburg, Russia
3. Institute of Experimental Medicine, St. Petersburg, Russia
4. Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20216704331      PubMed Id: 34414891
Year: 2021  Volume: 67  Issue: 4  Pages: 331-337
The pathogenetic mechanisms associated with alcohol use include dysregulation of the innate immune system mechanisms in the brain. TLR3 expression is increased in the postmortem material of the prefrontal cortex of humans. An increase in the TLR3 signaling activity leads to the induction of interferons (IFN). IFN are associated with depressive symptoms and, therefore, may play a role in the pathogenesis of alcoholism; however, the exact mechanisms of intracellular signaling mediated by the influence of ethanol are not fully elucidated and their study was the purpose of this work. The experimental results showed that ethanol and the TLR3 agonist Poly (I:C) increased the content of TLR3, IFNβ, and IFNγ mRNA in the prefrontal cortex. In addition, expression of the TRAIL encoding gene also increased, and this increase positively correlaed with the mRNA content of TLR3, IFNβ and IFNγ both under alcoholization conditions and after injections of the TLR3 agonist. The data obtained may indicate that alcoholization is able to activate TLR3-TRAIL-IFN-signaling in the prefrontal cortex of the brain.
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Keywords: brain, mPFC, long-term alcoholization, interferons, TLR3, TRAIL
Citation:

Airapetov, M. I., Eresko, S. O., Vasilev, A. K., Vasileva, V. Y., Bychkov, E. R., Lebedev, A. A., Shabanov, P. D. (2021). The TLR3 induction increases content of interferons in rat's brain by TRAIL signaling during long-term alcoholization. Biomeditsinskaya khimiya, 67(4), 331-337.
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