The effect of prenatal stress on antioxidant glutathion-assosiated enzymes activity in subcellular fractions of rat's liver

   
Vyushina A.V.1, Pritvorova A.V.1 , Semenova O.G.1, Ordyan N.E.1

1. Pavlov Institute of Physiology of the RAS, St. Petersburg, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20216704347      PubMed Id: 34414893
Year: 2021  Volume: 67  Issue: 4  Pages: 347-351
The activity of glutathione-associated antioxidant enzymes in subcellular fractions (cytosolic, mitochondrial, and cell nucleus fractions) was investigated in the liver of adult male Wistar rats born after prenatal stress was. Two groups of animals were studied in the experiment: (1) control group included — animals was born by intact mothers, and (2) prenatal stress group included animals whose mothers were subjected to immobilization stress in high-light conditions from the 15th to the 19th day of pregnancy. The activity of glutathione peroxidase (EC 1.11.1.9) in prenatally stressed animals decreased in the fractions of nuclei and mitochondria compared to the control group, while the activity of glutathione reductase (EC 1.8.1.7.) increased in the same subcellular fractions. The activity of glutathione transferase (EC 2.5.1.18) in prenatally stressed rats reduced in the cytosol and mitochondrial fractions as compared to control group. Redistribution of the antioxidant enzyme activity in the cytosol, the fraction of nuclei and the mitochondrial fraction of liver tissue may contribute to the formation of the pathological phenotype of prenatally stressed offspring.
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Keywords: prenatal stress, liver, glutathione peroxidase, glutathione reductase, glutathione transferase
Citation:

Vyushina, A. V., Pritvorova, A. V., Semenova, O. G., Ordyan, N. E. (2021). The effect of prenatal stress on antioxidant glutathion-assosiated enzymes activity in subcellular fractions of rat's liver. Biomeditsinskaya khimiya, 67(4), 347-351.
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