A pilot study of cytokine profile in cerebrospinal fluid of children with acute lymphocytic leukemia and neurotoxic side effects of chemotherapy

   
Bazarnyi V.V.1 , Kovtun O.P.1, Koryakina O.V.2, Polushina L.G.1, Maksimova A.Yu.1

1. Ural State Medical University, Yekaterinburg, Russia
2. Ural State Medical University, Yekaterinburg, Russia; Regional Children's Clinical Hospital, Yekaterinburg, Russia
Section: Short Communication
DOI: 10.18097/PBMC20216704374      PubMed Id: 34414897
Year: 2021  Volume: 67  Issue: 4  Pages: 374-377
In some cases standard chemotherapy of acute lymphocytic leukemia (ALL) leads to neurotoxicity; its mechanisms, methods of prognosis, and prevention are being actively studied. The aim of this study was to assess the cytokine profile in cerebrospinal fluid (CSF) of children with ALL and neurotoxic side effects of chemotherapy. This prospective study included 24 children with ALL aged from 3 to 17 years. Patients were further subdivided into ALL patients with (main group) and without neurological complications (comparison group). The level of cytokines in CSF was measured by Xmap technology (Luminex) using Invitrogen test systems (eBioscience) and the Luminex 200 system. The comparative analysis of the cytokine profile in the group of children with chemotherapy-induced neurotoxic complications revealed elevated levels of chemokine CXCL12 (SDF-1α) and stem cell factor (SCF). Increased level of these cytokines in CSF was characterized by a relatively risk for development of toxic peripheral neuropathy.
Download PDF:
Keywords: cytokines, acute lymphocytic leukemia, neurotoxicity
Citation:

Bazarnyi, V. V., Kovtun, O. P., Koryakina, O. V., Polushina, L. G., Maksimova, A. Yu. (2021). A pilot study of cytokine profile in cerebrospinal fluid of children with acute lymphocytic leukemia and neurotoxic side effects of chemotherapy. Biomeditsinskaya khimiya, 67(4), 374-377.
References  
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)