1. Faculty of Physics, M.V. Lomonosov Moscow State University, Moscow, Russia; Faculty of Medicine, Moscow University for Industry and Finance “Synergy”, Moscow, Russia 2. Faculty of Physics, M.V. Lomonosov Moscow State University, Moscow, Russia 3. Medical Institute of the Peoples' Friendship University of Russia, Moscow, Russia
The review considers the main molecular biological features of the COVID-19 causative agent, the SARS-CoV-2 virus: life cycle, viral cell penetration strategies, interactions of viral proteins with human proteins, cytopathic effects. We also analyze pathological conditions that occur both during the course of the COVID-19 disease and after virus elimination. A brief review of the biological activities of polysaccharides isolated from various sources is given, and possible molecular biological mechanisms of these activities are considered. Data analysis shows that polysaccharides are a class of biological molecules with wide potential for use in the treatment of both acute conditions in COVID-19 and post-COVID syndrome.
Generalov E.A., Simonenko E.Yu., Kulchenko N.G., Yakovenko L.V. (2022) Molecular basis of biological activity of polysaccharides in COVID-19 associated conditions. Biomeditsinskaya Khimiya, 68(6), 403-418.
Generalov E.A. et al. Molecular basis of biological activity of polysaccharides in COVID-19 associated conditions // Biomeditsinskaya Khimiya. - 2022. - V. 68. -N 6. - P. 403-418.
Generalov E.A. et al., "Molecular basis of biological activity of polysaccharides in COVID-19 associated conditions." Biomeditsinskaya Khimiya 68.6 (2022): 403-418.
Generalov, E. A., Simonenko, E. Yu., Kulchenko, N. G., Yakovenko, L. V. (2022). Molecular basis of biological activity of polysaccharides in COVID-19 associated conditions. Biomeditsinskaya Khimiya, 68(6), 403-418.
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