Ginsenosides affect the system of Toll-like receptors in the brain of rats under conditions of long-term alcohol withdrawal

   
Airapetov M.I.1 , Eresko S.O.2, Kochkin D.V.3, Bychkov E.R.4, Lebedev A.A.4, Shabanov P.D.5

1. Department of Neuropharmacology, Institute of Experimental Medicine, St. Petersburg, Russia; St. Petersburg State Pediatric Medical University, St. Petersburg, Russia
2. Department of Neuropharmacology, Institute of Experimental Medicine, St. Petersburg, Russia; Research and Training Center of Molecular and Cellular Technologies, St. Petersburg State Chemical Pharmaceutical University, St. Petersburg, Russia
3. Department of Plant Physiology, M.V. Lomonosov Moscow State University, Moscow, Russia; Timiryazev Institute of Plant Physiology of RAS, Moscow, Russia
4. Department of Neuropharmacology, Institute of Experimental Medicine, St. Petersburg, Russia
5. Department of Neuropharmacology, Institute of Experimental Medicine, St. Petersburg, Russia; Department of Pharmacology, Kirov Military Medical Academy, St. Petersburg, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20226806459      PubMed Id: 36573411
Year: 2022  Volume: 68  Issue: 6  Pages: 459-469
Long-term alcohol consumption causes the development of neuroinflammation in various brain structures. One of the mechanisms involved in this process is the increased activity of TLR-signaling intracellular pathways. Studies confirm the ability of ginseng extract or its individual ginsenosides to reduce the increased activity of TLR-signaling pathways. The aim of our study was to study the effect of the amount of ginsenosides obtained from the extract of the Panax japonicus cell line on the state of the TLR-signaling system in the nucleus accumbens and hippocampus of the rat brain in a model of long-term alcohol consumption during alcohol withdrawal. The results of the study showed that ginsenosides were able to make changes in the TLR signaling system, which has been altered by long-term alcohol consumption. A significant effect of ginsenosides on the level of TLR3 and TLR4 mRNA in the nucleus accumbens was found, while in the hippocampus, ginsenosides significantly affected the level of TLR7 mRNA. The effect of ginsenosides on the level of mRNA of transcription factors and cytokines involved in TLR-signaling was evaluated. Thus, results of our study confirm that ginsenosides are able to influence the state of TLR-signaling pathways, but this effect is multidirectional in relation to different brain structures. In the future, it seems interesting to evaluate the role of individual ginsenosides in relation to genes of TLR-signaling, as well as the effect of ginsenosides on other brain structures.
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Keywords: ginsenosides, brain, neuroinflammation, TLR, nucleus accumbens, hippocampus
Citation:

Airapetov, M. I., Eresko, S. O., Kochkin, D. V., Bychkov, E. R., Lebedev, A. A., Shabanov, P. D. (2022). Ginsenosides affect the system of Toll-like receptors in the brain of rats under conditions of long-term alcohol withdrawal. Biomeditsinskaya Khimiya, 68(6), 459-469.
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