Pharmacological importance of novel spiro derivatives against human pathogenic fungi

Sharma G.1, Sharma R.2 , Saxena R.3, Rajni E.2, Prakash Mamoria V.2

1. Department of Chemistry, MPS International, Jaipur, Rajasthan, India
2. Department of Microbiology, Mahatma Gandhi University of Medical Sciences & Technology, Jaipur, Rajasthan, India
3. Department of Biotechnology, Invertis University, Bareilly, Uttar Pradesh, India
Section: Experimental Study
DOI: 10.18097/PBMC20236901055      PubMed Id: 36857427
Year: 2023  Volume: 69  Issue: 1  Pages: 55-61
Human mycoses have become a threat to health world-wide. Unfortunately there are only a limited number of antimycotic drugs in use. In the present study, antifungal activity of earlier synthesized spiro-1,4-dihydropyridines (1,4-DHPs) was investigated. The antifungal activity of spiro-1,4-DHPs compounds were screened against Aspergillus flavus, A. fumigatus, and Candida albicans by using Disc Diffusion and Modified Microdilution method. Among six spiro-1,4-DHPs compounds tested all of them showed stronger antifungal activity possibly through inhibiting the synthesis of chitin in cell wall against A. flavus, A. fumigatus, and C. albicans as compared to fluconazole, a standard antifungal drug. The combination of compounds showed that the synthesized compounds had synergistic, additive effects as compared to currently used drugs as an antifungal agent. These results indicated that these designed compounds were potential chitin synthase inhibitors and had excellent antimycotic activity for the treatment of fungal infections.
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Keywords: spiro-1,4-DHPs, drug resistant, fungi, combination, drugs, antimycotic

Sharma, G., Sharma, R., Saxena, R., Rajni, E., Prakash, Mamoria, V. (2023). Pharmacological importance of novel spiro derivatives against human pathogenic fungi. Biomeditsinskaya Khimiya, 69(1), 55-61.
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