Effect of erastin and G3139 on rat liver mitochondria in chronic alcoholic intoxication

Baburina Yu.L.1 , Zvyagina A.I.1, Odinokova I.V.1, Krestinina O.V.1

1. Institute of Theoretical and Experimental Biophysics of the Russian Academy of Science, Pushchino, Russia
Section: Experimental Study
DOI: 10.18097/PBMC20236901062      PubMed Id: 36857428
Year: 2023  Volume: 69  Issue: 1  Pages: 62-71
The effect of modulators of VDAC channels — G3139 and erastin on the mitochondrial permeability transition pore (mPTP) functioning and changes in the content of proteins involved in regulation of mPTP (VDAC, CNPase, and TSPO) has been investigated in liver mitochondria of rats with chronic alcohol intoxication. It was shown that the mitochondria of rats treated with ethanol were more sensitive to mPTP induction. Moreover, ethanol induced changes in the expression of mPTP regulator proteins. G3139 and erastin were also able to influence the studied mitochondrial parameters, and they increased their effect in the liver mitochondria of rats treated with ethanol, as compared to the mitochondria of control rats. We hypothesize that the results of this study may help to elucidate the mechanisms of chronic action of ethanol on mitochondria and contribute to the development of new therapeutic strategies for treating the consequences of ethanol-related diseases.
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Keywords: mitochondrial nonspecific pore (mPTP), voltage-dependent anion channel (VDAC), chronic alcohol intoxication, erastin

Baburina, Yu. L., Zvyagina, A. I., Odinokova, I. V., Krestinina, O. V. (2023). Effect of erastin and G3139 on rat liver mitochondria in chronic alcoholic intoxication. Biomeditsinskaya Khimiya, 69(1), 62-71.
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