The development of experimental alloxan diabetes in rats was accompanied by the increase the activity of liver NAD⁺- and NADP⁺-dependent malic enzymes (ME; NAD⁺-ME, EC 1.1.1.39 and NADP⁺-ME, 1.1.1.40) associated with an increase in the rate of transcription of genes encoding these enzymes. Oral administration of aqueous extracts of Jerusalem artichoke and olive to diabetic rats caused a noticeable decrease in blood glucose, a decrease in the rate of transcription of the studied genes; and a decrease in ME activity towards normal values. Thus, extracts of Jerusalem artichoke and olive can be used as additives to the standard therapy of diabetes mellitus.
Eprintsev A.T., Selivanova N.V. (2023) The effect of phytoprotectors on the functioning of liver NAD⁺- and NADP⁺-maliс enzymes in rats with alloxan diabetes. Biomeditsinskaya Khimiya, 69(2), 104-111.
Eprintsev A.T. et al. The effect of phytoprotectors on the functioning of liver NAD⁺- and NADP⁺-maliс enzymes in rats with alloxan diabetes // Biomeditsinskaya Khimiya. - 2023. - V. 69. -N 2. - P. 104-111.
Eprintsev A.T. et al., "The effect of phytoprotectors on the functioning of liver NAD⁺- and NADP⁺-maliс enzymes in rats with alloxan diabetes." Biomeditsinskaya Khimiya 69.2 (2023): 104-111.
Eprintsev, A. T., Selivanova, N. V. (2023). The effect of phytoprotectors on the functioning of liver NAD⁺- and NADP⁺-maliс enzymes in rats with alloxan diabetes. Biomeditsinskaya Khimiya, 69(2), 104-111.
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