Features of oxidative stress in alcoholism

Prokopieva V.D.1, Vetlugina T.P.1

1. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia
Section: Review
DOI: 10.18097/PBMC20236902083      PubMed Id: 37132490
Year: 2023  Volume: 69  Issue: 2  Pages: 83-96
The review considers molecular mechanisms underlying formation and development of oxidative stress (OS) in patients with alcohol dependence. The major attention is paid to the effects of ethanol and its metabolite acetaldehyde associated with additional sources of generation of reactive oxygen species (ROS) in response to exogenous ethanol. The own results of studies of the in vitro effect of ethanol and acetaldehyde on the concentration of peripheral OS markers — products of oxidative modification of proteins (protein carbonyls), lipids (lipid peroxidation products), DNA (8-hydroxy-2-deoxyguanosine, 8-OHdG) in blood plasma are presented. The changes in these parameters and the activity of antioxidant enzymes (SOD, catalase) in patients with alcohol dependence were analyzed. Own and literature data indicate that at a certain stage of the disease OS can play a protective rather than pathogenic role in the body.
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Keywords: oxidative stress, reactive oxygen species, peripheral markers of oxidative stress, ethanol, alcoholism

Prokopieva, V. D., Vetlugina, T. P. (2023). Features of oxidative stress in alcoholism. Biomeditsinskaya Khimiya, 69(2), 83-96.
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