The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol
Oktar Süleyman1 , Karadeniz Mahinur2, Acar Musa3, Zararsız İsmail4
1. University of Health Sciences, Beyhekim Training and Research Hospital, Department of Pharmacology, Konya, Turkey 2. Selçuklu District Health Directorate, Selçuklu, Konya, Turkey 3. Necmettin Erbakan University, Faculty of Health Sciences, Department of Physical Therapy and Rehabilitation, Konya, Turkey 4. Girne American University, Medical Faculty, Department of Anatomy, Girne, Cyprus
The toxic effect of ethanol on the cerebral cortex and protective effects of omega-3 fatty acids against this neurotoxicity were investigated. Twenty eight male Wistar-albino rats were divided into 4 groups. Rats of the ethanol and ethanol withdrawal groups were treated with ethanol (6 g/kg/day) for 15 days. Animals of the ethanol+omega-3 group received omega-3 fatty acids (400 mg/kg daily) and ethanol. In rats of the ethanol group SOD activity was lower than in animals of the control group. In rats treated with omega-3 fatty acids along with ethanol SOD, activity increased. GSH-Px activity and MDA levels in animals of all groups were similar. In ethanol treated rats NO levels significantly decreased as compared to the animals of the control group (6.45±0.24 nmol/g vs 11.05±0.53 nmol/g, p<0.001). In rats receiving ethanol+omega-3, there was a significant increase in the NO level as compared to animals of the ethanol group (13.12±0.37 nmol/g vs 6.45±0.24 nmol/g, p<0.001). Thus, ethanol administration leads to oxidative damage and a decrease in the NO level. Omega-3 fatty acids have a protective role against ethanol induced oxidative damage and normalize the NO level.
Oktar Süleyman, Karadeniz Mahinur, Acar Musa, Zararsız İsmail (2024) The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol. Biomeditsinskaya Khimiya, 70(2), 83-88.
Oktar Süleyman et al. The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol // Biomeditsinskaya Khimiya. - 2024. - V. 70. -N 2. - P. 83-88.
Oktar Süleyman et al., "The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol." Biomeditsinskaya Khimiya 70.2 (2024): 83-88.
Oktar, Süleyman,, Karadeniz, Mahinur,, Acar, Musa,, Zararsız, İsmail (2024). The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol. Biomeditsinskaya Khimiya, 70(2), 83-88.
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