Genitourinary cancer (GUC) represents more than one fifth of all human cancers. This makes the development of approaches to its early diagnosis an important task of modern biomedicine. Circulating microRNAs, short (17–25 nucleotides) non-coding RNA molecules found in human biological fluids and performing a regulatory role in the cell, are considered as promising diagnostic and prognostic biomarkers of cancers, including GUC. In this review we have considered the current state of research aimed at assessing microRNAs as biomarkers of such human GUC types as malignant tumors of the bladder, kidney, prostate, testicles, ovaries, and cervix. A special attention has been paid to studies devoted to the identification of microRNAs in urine as a surrogate “liquid biopsy” that may provide the simplest and cheapest approach to mass non-invasive screening of human GUC. The use of microRNA panels instead of single types of microRNA generally leads to higher sensitivity and specificity of the developed diagnostic tests. However, to date, work on the microRNAs assessment as biomarkers of human GUC is still of a research nature, and the further introduction of diagnostic tests based on microRNAs into practice requires successful clinical trials.
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Keywords: cancer, human genitourinary system, microRNA, diagnostic markers
Citation:
Kugaevskaya E.V., Timoshenko O.S., Gureeva T.A., Radko S.P., Lisitsa A.V. (2024) MicroRNAs as promising diagnostic and prognostic markers for the human genitourinary cancer. Biomeditsinskaya Khimiya, 70(4), 191-205.
Kugaevskaya E.V. et al. MicroRNAs as promising diagnostic and prognostic markers for the human genitourinary cancer // Biomeditsinskaya Khimiya. - 2024. - V. 70. -N 4. - P. 191-205.
Kugaevskaya E.V. et al., "MicroRNAs as promising diagnostic and prognostic markers for the human genitourinary cancer." Biomeditsinskaya Khimiya 70.4 (2024): 191-205.
Kugaevskaya, E. V., Timoshenko, O. S., Gureeva, T. A., Radko, S. P., Lisitsa, A. V. (2024). MicroRNAs as promising diagnostic and prognostic markers for the human genitourinary cancer. Biomeditsinskaya Khimiya, 70(4), 191-205.
References
Bellmunt J., Orsola A., Leow J.J., Wiegel T., de Santis M., Horwich A. (2014) Bladder cancer: ESMO Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 25(Suppl 3), iii40–iii48. CrossRef Scholar google search
Parker C., Gillessen S., Heidenreich A., Horwich A. (2015) Cancer of the prostate: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 26, 69–77. CrossRef Scholar google search
Marth C., Landoni F., Mahner S., McCormack M., Gonzalez-Martin A., Colombo N. (2017) Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 28(Suppl 4), 72–83. CrossRef Scholar google search
Colombo N., Preti E., Landoni F., Carinelli S., Colombo A., Marini C. (2013) ESMO Guidelines Working Group Endometrial cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 24(Suppl 6), 33–38. CrossRef Scholar google search
Ray-Coquard I., Morice P., Lorusso D., Prat J., Oaknin A., Pautier P., Colombo N. (2018) ESMO Guidelines Committee Non-epithelial Ovarian cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 29(Suppl 4), 1–18. CrossRef Scholar google search
Escudier B., Porta C., Schmidinger M., Rioux-Leclercq N., Bex A., Khoo V., Grünwald V., Gillessen S., Horwich A. (2019) ESMO Guidelines Committee Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol., 30(5), 706–720. CrossRef Scholar google search
Colombo N., Sessa C., du Bois A., Ledermann J., McCluggage W.G., McNeish I., Morice P., Pignata S., Ray-Coquard I., Vergote I., Baert T., Belaroussi I., Dashora A., Olbrecht S., Planchamp F., Querleu D. (2019) ESMO-ESGO consensus conference recommendations on ovarian cancer: Pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease. Ann. Oncol., 30(5), 672–705. CrossRef Scholar google search
Tolou Ghamari Z., Mazdak H., Saboori M., Sichani M. (2019) Genitourinary tract cancers: Frequency and demographic characteristics. Clin. Cancer Investig. J., 8(6), 232–235. CrossRef Scholar google search
Schafer E.J., Jemal A., Wiese D., Sung H., Kratzer T.B., Islami F., Dahut W.L., Knudsen K.E. (2023) Disparities and trends in genitourinary cancer incidence and mortality in the USA. Eur. Urol., 84(1), 117–126. CrossRef Scholar google search
Yuvaraja T.B., Waigankar S., Bakshi G., Prakash G. (2016) Genitourinary cancers: Summary of Indian data. South Asian J. Cancer, 5(3), 122–124. CrossRef Scholar google search
Ferlay J., Colombet M., Soerjomataram I., Mathers C., Parkin D.M., Piñeros M., Znaor A., Bray F. (2019) Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int. J. Cancer., 144(8), 1941–1953. CrossRef Scholar google search
Bankhead C.R., Kehoe S.T., Austoker J. (2005) Symptoms associated with diagnosis of ovarian cancer: A systematic review. BJOG, 112(7), 857–865. CrossRef Scholar google search
Vlasova M.A., Moshkovskiy S.A., Safarova M.P., Makarov O.V., Archakov A.I. (2005) Molecular diagnostics of ovarian cancer using proteome techniques. Biomeditsinskaya Khimiya, 51(4), 367–383. Scholar google search
Holcakova J., Bartosik M., Anton M., Minar L., Hausnerova J., Bednarikova M., Weinberger V., Hrstka R. (2021) New trends in the detection of gynecological precancerous lesions and early-stage cancers. Cancers (Basel), 13(24), 6339. CrossRef Scholar google search
O'Donoghue P.M., McSweeney S.E., Jhaveri K. (2010) Genitourinary imaging: Current and emerging applications. J. Postgrad. Med., 56(2), 131–139. CrossRef Scholar google search
Merae Alshahrani M. (2022) A glance at the emerging diagnostic biomarkers in the most prevalent genitourinary cancers. Saudi. J. Biol. Sci., 29(4), 2072–2084. CrossRef Scholar google search
Hemenway G., Anker J.F., Riviere P., Rose B.S., Galsky M.D., Ghatalia P. (2024) Advancements in urothelial cancer care: Optimizing treatment for your patient. Am. Soc. Clin. Oncol. Educ. Book, 44(3), e432054. CrossRef Scholar google search
Montironi R., Santoni M., Cimadamore A., Lopez-Beltran A., Cheng L. (2019) Editorial: Emerging biomarkers in genitourinary tumors. Front. Oncol., 9, 326. CrossRef Scholar google search
Aveta A., Cilio S., Contieri R., Spena G., Napolitano L., Manfredi C., Franco A., Crocerossa F., Cerrato C., Ferro M., del Giudice F., Verze P., Lasorsa F., Salonia A., Nair R., Walz J., Lucarelli G., Pandolfo S.D. (2023) Urinary microRNAs as biomarkers of urological cancers: A systematic review. Int. J. Mol. Sci., 24(13), 10846. CrossRef Scholar google search
Saw P.E., Xu X., Chen J., Song E.W. (2021) Non-coding RNAs: The new central dogma of cancer biology. Sci. China Life Sci., 64(1), 22–50. CrossRef Scholar google search
Saliminejad K., Khorram Khorshid H.R., Soleymani Fard S., Ghaffari S.H. (2019) An overview of microRNAs: Biology, functions, therapeutics, and analysis methods. J. Cell. Physiol., 234(5), 5451–5465. CrossRef Scholar google search
Nie J.H., Li T.X., Zhang X.Q., Liu J. (2019) Roles of non-coding RNAs in normal human brain development, brain tumor, and neuropsychiatric disorders. Noncoding RNA, 5(2), 36. CrossRef Scholar google search
Friedman R.C., Farh K.K., Burge C.B., Bartel D.P. (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res., 19(1), 92–105. CrossRef Scholar google search
Budakoti M., Panwar A.S., Molpa D., Singh R.K., Büsselberg D., Mishra A.P., Coutinho H.D.M, Nigam M. (2021) Micro-RNA: The darkhorse of cancer. Cell. Signal., 83, 109995. CrossRef Scholar google search
Yu X., Li Z., Shen J., Wu W.K., Liang J., Weng X., Qiu G. (2013) MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. PLoS ONE, 8(12), 83080. CrossRef Scholar google search
Ha M., Kim V.N. (2014) Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell. Biol., 15(8), 509–524. CrossRef Scholar google search
Rupaimoole R., Slack F.J. (2017) MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat. Rev. Drug Discov., 16(3), 203–222. CrossRef Scholar google search
Pritchard C.C., Cheng H.H., Tewari M. (2012) MicroRNA profiling: Approaches and considerations. Nat. Rev. Genet., 13(5), 358–369. CrossRef Scholar google search
Smagulova A., Uakhit R., Kiyan V. (2022) First record of Alternaria alternata causing necrosis of Thuja (Thuja occidentalis) in Kazakhstan. Plant Dis., 2022, DOI: 10.1094/PDIS-11-21-2523-PDN. CrossRef Scholar google search
Vilimova M., Pfeffer S. (2023) Post-transcriptional regulation of polycistronic microRNAs. Wiley Interdiscip. Rev. RNA, 14(2), e1749. CrossRef Scholar google search
Zaporozhchenko I.A., Rykova E.Y., Laktionov P.P. (2020) The fundamentals of miRNA biology: Structure, biogenesis, and regulatory functions. Russ. J. Bioorg. Chem., 46, 1–13. DOI: 10.1134/S106816202001015X CrossRef Scholar google search
Martinez I., Hayes K.E., Barr J.A., Harold A.D., Xie M., Bukhari S.I.A., Vasudevan S., Steitz J.A., di Maio D. (2017) An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. Proc. Natl. Acad. Sci. USA, 114(25), E4961–E4970. CrossRef Scholar google search
Tétreault N., de Guire V. (2013) miRNAs: Their discovery, biogenesis and mechanism of action. Clin. Biochem., 46(10–11), 842–845. CrossRef Scholar google search
Rani V., Sengar R.S. (2022) Biogenesis and mechanisms of microRNA-mediated gene regulation. Biotechnol. Bioeng., 119(3), 685–692. CrossRef Scholar google search
O'Brien J., Hayder H., Zayed Y., Peng C. (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front. Endocrinol. (Lausanne), 9, 402. CrossRef Scholar google search
Wu Q., Li L., Jia Y., Xu T., Zhou X. (2023) Advances in studies of circulating microRNAs: Origination, transportation, and distal target regulation. J. Cell. Commun. Signal., 17(3), 445–455. CrossRef Scholar google search
Lohajová Behulová R., Bugalová A., Bugala J., Struhárňanská E., Šafranek M., Juráš I. (2023) Circulating exosomal miRNAs as a promising diagnostic biomarker in cancer. Physiol. Res., 72(S3), S193–S207. CrossRef Scholar google search
Bayraktar R., van Roosbroeck K., Calin G.A. (2017) Cell-to-cell communication: microRNAs as hormones. Mol. Oncol., 11(12), 1673–1686. CrossRef Scholar google search
Cortez M.A., Bueso-Ramos C., Ferdin J., Lopez-Berestein G., Sood A.K., Calin G.A. (2011) MicroRNAs in body fluids — the mix of hormones and biomarkers. Nat. Rev. Clin. Oncol., 8(8), 467–477. CrossRef Scholar google search
Lee R.C., Feinbaum R.L., Ambros V. (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 75(5), 843–854. CrossRef Scholar google search
Yaylak B., Akgül B. (2022) Experimental microRNA detection methods. Methods Mol. Biol., 2257, 33–55. CrossRef Scholar google search
Bodulev O.L., Sakharov I.Yu. (2022) Modern methods for determining microRNA. Biokhimiya, 87(4), 474–496. CrossRef Scholar google search
Zhang J., Li Z., Wang H., Wang Y., Jia H., Yan J. (2011) Ultrasensitive quantification of mature microRNAs by real-time PCR based on ligation of a ribonucleotidemodified DNA probe. Chem. Commun., 47(33), 9465–9467. CrossRef Scholar google search
Chen C., Ridzon D.A., Broomer A.J., Zhou Z., Lee D.H., Nguyen J.T., Barbisin M., Xu N.L., Mahuvakar V.R., Andersen M.R., Lao K.Q., Livak K.J., Guegler K.J. (2005) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res., 33(20), e179. CrossRef Scholar google search
Androvic P., Valihrach L., Elling J., Sjoback R., Kubista M. (2017) Two-tailed RT-qPCR: A novel method for highly accurate miRNA quantification. Nucleic Acids Res., 45(15), e144. CrossRef Scholar google search
Kiseleva Y.Y., Ptitsyn K.G., Radko S.P., Zgoda V.G., Archakov A.I. (2016) Digital droplet PCR — a prospective technological approach to quantitative profiling of microRNA. Biomeditsinskaya Khimiya, 62(4), 403–410. CrossRef Scholar google search
Cirillo P.D.R., Margiotti K., Mesoraca A., Giorlandino C. (2020) Quantification of circulating microRNAs by droplet digital PCR for cancer detection. BMC Res. Notes., 13(1), 351. CrossRef Scholar google search
Ambros V., Bartel B., Bartel D.P., Burge C.B., Carrington J.C., Chen X., Dreyfuss G., Eddy S.R., Griffiths-Jones S., Marshall M., Matzke M., Ruvkun G., Tuschl T. (2003) A uniform system for microRNA annotation. RNA, 9(3), 277–279. CrossRef Scholar google search
Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. (2018) Global cancer statistics GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 68(6), 394–424. CrossRef Scholar google search
Witjes J.A., Compérat E., Cowan N.C., de Santis M., Gakis G., Lebret T., Ribal M.J., van der Heijden A.G., Sherif A. (2014) European Association of Urology. EAU guidelines on muscle-invasive and metastatic bladder cancer: Summary of the 2013 guidelines. Eur. Urol., 65(4), 778–792. CrossRef Scholar google search
Cumberbatch M.G.K., Noon A.P. (2019) Epidemiology, aetiology and screening of bladder cancer. Transl. Androl. Urol., 8(1), 5–11. CrossRef Scholar google search
de George K.C., Holt H.R., Hodges S.C. (2017) Bladder cancer: Diagnosis and treatment. Am. Fam. Physician, 96(8), 507–514. PMID: 29094888. Scholar google search
Kamat A.M., Hahn N.M., Efstathiou J.A., Lerner S.P., Malmström P.U., Choi W., Guo C.C., Lotan Y., Kassouf W. (2016) Bladder cancer. Lancet, 388(10061), 2796–2810. CrossRef Scholar google search
Li Y., Li G., Guo X., Yao H., Wang G., Li C. (2020) Non-coding RNA in bladder cancer. Cancer Lett., 485, 38–44. CrossRef Scholar google search
Li X., Chen J., Hu X., Huang Y., Li Z., Zhou L., Tian Z., Ma H., Zhiyun Wu Z., Chen M., Han Z., Peng Z., Zhao X., Liang C., Wang Y., Sun L., Chen J., Zhao J., Jiang B., Yang H., Gui Y., Cai Z., Zhang X. (2011) Comparative mRNA and microRNA expression profiling of three genitourinary cancers reveals common hallmarks and cancer-specific molecular events. PLoS ONE, 6(7), e22570. CrossRef Scholar google search
Guo A.-Y., Sun J., Jia P., Zhao Z. (2010) A novel microRNA and transcription factor mediated regulatory network in schizophrenia. BMC Syst. Biol., 4(1), 10. CrossRef Scholar google search
Dong F., Xu T., Shen Y., Zhong S., Chen S., Ding Q., Shen Z. (2017) Dysregulation of miRNAs in bladder cancer: Altered expression with aberrant biogenesis procedure. Oncotarget, 8(16), 27547. CrossRef Scholar google search
Chen Y.-H., Wang S.-Q., Wu X.-L., Shen M., Chen Z.-G., Chen X.-G., Liu Y.-X., Zhu X.-L., Guo F., Duan X.-Z., Han X.-C., Tao Z.-H. (2013) Characterization of microRNAs expression profiling in one group of Chinese urothelial cell carcinoma identified by Solexa sequencing. Urol. Oncol., 31(2), 219–227. CrossRef Scholar google search
Parizi P.K., Yarahmadi F., Tabar H.M., Hosseini Z., Sarli A., Kia N., Tafazoli A., Esmaeili S.A. (2020) MicroRNAs and target molecules in bladder cancer. Med. Oncol., 37(12), 118. CrossRef Scholar google search
Lin J.T., Tsai K.W. (2021) Circulating miRNAs act as diagnostic biomarkers for bladder cancer in urine. Int. J. Mol. Sci., 22(8), 4278. CrossRef Scholar google search
Pospisilova S., Pazourkova E., Horinek A., Brisuda A., Svobodova I., Soukup V., Hrbacek J., Capoun O., Hanus T., Mares J., Korabecna M., Babjuk M. (2016) MicroRNAs in urine supernatant as potential non-invasive markers for bladder cancer detection. Neoplasma, 63(5), 799–808. CrossRef Scholar google search
Zhang D.-Z., Lau K.-M., Chan E.S.Y., Wang G., Szeto C.-C., Wong K., Choy R.K.W., Ng C.-F. (2014) Cell-free urinary microRNA-99a and microRNA-125b are diagnostic markers for the non-invasive screening of bladder cancer. PLoS ONE, 9(7), e100793. CrossRef Scholar google search
Zaidi N., Siddiqui Z., Sankhwar S.N., Srivastava A.N. (2023) Urinary microRNA-10a levels in diagnosis and prognosis of urinary bladder cancer. J. Cancer Res. Ther., 19(5), 1324–1329. CrossRef Scholar google search
Juracek J., Peltanova B., Dolezel J., Fedorko M., Pacik D., Radova L., Vesela P., Svoboda M., Slaby O., Stanik M. (2018) Genome-wide identification of urinary cell-free microRNAs for noninvasive detection of bladder cancer. J. Cell. Mol. Med., 22(3), 2033–2038. CrossRef Scholar google search
Pardini B., Cordero F., Naccarati A., Viberti C., Birolo G., Oderda M., di Gaetano C., Arigoni M., Martina F., Calogero R.A., Sacerdote C., Gontero P., Vineis P., Matullo G. (2018) MicroRNA profiles in urine by next-generation sequencing can stratify bladder cancer subtypes. Oncotarget, 9(29), 20658–20669. CrossRef Scholar google search
Tölle A., Jung M., Rabenhorst S., Kilic E., Jung K., Weikert S. (2013) Identification of microRNAs in blood and urine as tumour markers for the detection of urinary bladder cancer. Oncol. Rep., 30(4), 1949–1956. CrossRef Scholar google search
Lopez-Beltran A., Cheng L., Gevaert T., Blanca A., Cimadamore A., Santoni M., Massari F., Scarpelli M., Raspollini M.R., Montironi R. (2020) Current and emerging bladder cancer biomarkers with an emphasis on urine biomarkers. Expert Rev. Mol. Diagn., 20(2), 231–243. CrossRef Scholar google search
Chen L., Cui Z., Liu Y., Bai Y., Lan F. (2015) MicroRNAs as biomarkers for the diagnostics of bladder cancer: A meta-analysis. Clin. Lab., 61(8), 1101–1108. CrossRef Scholar google search
El-Shal A.S., Shalaby S.M., Abouhashem S.E., Elbary E.H.A., Azazy S., Rashad N.M., Sarhan W. (2021) Urinary exosomal microRNA-96-5p and microRNA-183-5p expression as potential biomarkers of bladder cancer. Mol. Biol. Rep., 48(5), 4361–4371. CrossRef Scholar google search
Hanke M., Hoefig K., Merz H., Feller A.C., Kausch I., Jocham D., Warnecke J.M., Sczakiel G. (2010) A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol. Oncol., 28(6), 655–661. CrossRef Scholar google search
Kutwin P., Borkowska E.M., Bogucka P., Jabłonowski Z. (2021) Expression profile of microRNAs (106b-3p, 130b-3, 145-3p, 199a-5p) in urine and serum samples from patients with the diagnosis of bladder cancer. Polski Merkuriusz Lekarski, 49(290), 103–107. CrossRef Scholar google search
Malekmohammad K., Gholampour F. (2023) Kidney cancer and microRNAs as novel biomarkers and tumor suppressors. Curr. Drug Discov. Technol., 20(3), e100123212531. CrossRef Scholar google search
Ghafouri-Fard S., Shirvani-Farsani Z., Branicki W., Taheri M. (2020) MicroRNA signature in renal cell carcinoma. Front. Oncol., 10, 596359. CrossRef Scholar google search
Mytsyk Y., Dosenko V., Skrzypczyk M.A., Borys Y., Diychuk Y., Kucher A., Kowalskyy V., Pasichnyk S., Mytsyk O., Manyuk L. (2018) Potential clinical applications of microRNAs as biomarkers for renal cell carcinoma. Cent. European J. Urol., 71(3), 295–303. CrossRef Scholar google search
Li M., Wang Y., Song Y., Bu R., Yin B., Fei X., Guo Q., Wu B. (2015) MicroRNAs in renal cell carcinoma: A systematic review of clinical implications. Oncol. Rep., 33(4), 1571–1578. CrossRef Scholar google search
Yang L., Zou X., Zou J., Zhang G. (2021) Review of recent research on the role of microRNAs in renal cancer. Med. Sci.Monit., 27, e930639. CrossRef Scholar google search
Petejova N., Martinek A. (2016) Renal cell carcinoma: Review of etiology, pathophysiology and risk factors. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub., 160(2), 183–194. CrossRef Scholar google search
Brufau B.P., Cerqueda C.S., Villalba L.B., Izquierdo R.S., González B.M., Molina C.N. (2013) Metastatic renal cell carcinoma: Radiologic findings and assessment of response to targeted antiangiogenic therapy by using multidetector CT. RadioGraphics, 33(6), 1691–1716. CrossRef Scholar google search
Cinque A., Vago R., Trevisani F. (2021) Circulating RNA in kidney cancer: What we know and what we still suppose. Genes (Basel), 12(6), 835. CrossRef Scholar google search
Cochetti G., Cari L., Nocentini G., Maulà V., Suvieri C., Cagnani R., Rossi de Vermandois J.A., Mearini E. (2020) Detection of urinary miRNAs for diagnosis of clear cell renal cell carcinoma. Sci. Rep., 10(1), 21290. CrossRef Scholar google search
Li G., Zhao A., Péoch M., Cottier M., Mottet N. (2017) Detection of urinary cell-free miR-210 as a potential tool of liquid biopsy for clear cell renal cell carcinoma. Urol. Oncol., 35(5), 294–299. CrossRef Scholar google search
Outeiro-Pinho G., Barros-Silva D., Aznar E., Sousa A.I., Vieira-Coimbra M., Oliveira J., Gonçalves C.S., Costa B.M., Junker K., Henrique R., Jerónimo C. (2020) MicroRNA-30a-5pme: A novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma in tissue and urine samples. J. Exp. Clin. Cancer Res., 39(1), 98. CrossRef Scholar google search
von Brandenstein M., Schlosser M., Herden J., Heidenreich A., Störkel S., Fries J.W.U. (2018) MicroRNAs as urinary biomarker for oncocytoma. Dis. Markers, 2018, 6979073. CrossRef Scholar google search
di Meo A., Brown M.D., Finelli A., Jewett M.A.S., Diamandis E.P., Yousef G.M. (2020) Prognostic urinary miRNAs for the assessment of small renal masses. Clin. Biochem., 75, 15–22. CrossRef Scholar google search
Borges dos Reis R., Shu X., Ye Y., Borregales L., Karam J.A., Adibi M., Wu X., Reis L.O., Wood C.G. (2024) Urinary miRNAs predict metastasis in patients with clinically localized clear cell renal cell carcinoma treated with nephrectomy. Clin. Genitourin. Cancer, 22(1), e156-e162.e4. CrossRef Scholar google search
Petrozza V., Costantini M., Tito C., Giammusso L.M., Sorrentino V., Cacciotti J., Porta N., Iaiza A., Pastore A.L., di Carlo A., Simone G., Carbone A., Gallucci M., Fazi F. (2020) Emerging role of secreted miR-210-3p as potential biomarker for clear cell renal cell carcinoma metastasis. Cancer Biomark., 27(2), 181–188. CrossRef Scholar google search
Fedorko M., Juracek J., Stanik M., Svoboda M., Poprach A., Buchler T., Pacik D., Dolezel J., Slaby O. (2017) Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. Biochem. Med. (Zagreb), 27(2), 411–417. CrossRef Scholar google search
Siegel R.L., Miller K.D., Fuchs H.E., Jemal A. (2022) Cancer statistics, 2022. CA Cancer J. Clin., 72(1), 7–33. CrossRef Scholar google search
Carter H.B., Albertsen P.C., Barry M.J., Etzioni R., Freedland S.J., Greene K.L., Holmberg L., Kantoff P., Konety B.R., Murad M.H., Penson D.F., Zietman A.L. (2013) Early detection of prostate cancer: AUA Guideline. J. Urol., 190(2), 419–426. CrossRef Scholar google search
Dejous C., Krishnan U.M. (2020) Sensors for diagnosis of prostate cancer: Looking beyond the prostate specific antigen. Biosens. Bioelectron., 173, 112790. CrossRef Scholar google search
Koh Y., Bustos M.A., Moon J., Gross R., Ramos R.I., Ryu S., Choe J., Lin S.Y., Allen W.M., Krasne D.L., Wilson T.G., Hoon D.S.B. (2022) Urine cell-free microRNAs in localized prostate cancer patients. Cancers (Basel), 14(10), 2388. CrossRef Scholar google search
Hasanoğlu S., Göncü B., Yücesan E., Atasoy S., Kayalı Y., Özten Kandaş N. (2021) Investigating differential miRNA expression profiling using serum and urine specimens for detecting potential biomarkers for early prostate cancer diagnosis. Turk. J. Med. Sci., 51(4), 1764–1774. CrossRef Scholar google search
Srivastava A., Goldberger H., Dimtchev A., Ramalinga M., Chijioke J., Marian C., Oermann E.K., Uhm S., Kim J.S., Chen L.N., Li X., Berry D.L., Kallakury B.V., Chauhan S.C., Collins S.P., Suy S., Kumar D. (2013) MicroRNA profiling in prostate cancer — the diagnostic potential of urinary miR-205 and miR-214. PLoS ONE, 8(10), e76994. CrossRef Scholar google search
Bryant R.J., Pawlowski T., Catto J.W., Marsden G., Vessella R.L., Rhees B., Kuslich C., Visakorpi T., Hamdy F.C. (2012) Changes in circulating microRNA levels associated with prostate cancer. Br. J. Cancer, 106(4), 768–774. CrossRef Scholar google search
Danarto R., Astuti I., Umbas R., Haryana S.M. (2019) Urine miR-21-5p and miR-200c-3p as potential non-invasive biomarkers in patients with prostate cancer. Turk. J. Urol., 46(1), 26-30. CrossRef Scholar google search
Jeon J., Olkhov-Mitsel E., Xie H., Yao C.Q., Zhao F., Jahangiri S., Cuizon C., Scarcello S., Jeyapala R., Watson J.D., Fraser M., Ray J., Commisso K., Loblaw A., Fleshner N.E., Bristow R.G., Downes M., Vesprini D., Liu S., Bapat B., Boutros P.C. (2020) Temporal stability and prognostic biomarker potential of the prostate cancer urine miRNA transcriptome. J. Natl. Cancer Inst., 112(3), 247–255. CrossRef Scholar google search
Haj-Ahmad T.A., Abdalla M.A., Haj-Ahmad Y. (2014) Potential urinary miRNA biomarker candidates for the accurate detection of prostate cancer among benign prostatic hyperplasia patients. J. Cancer, 5(3), 182–191. CrossRef Scholar google search
Byun Y.J., Piao X.M., Jeong P., Kang H.W., Seo S.P., Moon S.K., Lee J.Y., Choi Y.H., Lee H.Y., Kim W.T., Lee S.C., Cha E.J., Yun S.J., Kim W.J. (2021) Urinary microRNA-1913 to microRNA-3659 expression ratio as a non-invasive diagnostic biomarker for prostate cancer. Investig. Clin. Urol., 62(3), 340–348. CrossRef Scholar google search
Fredsøe J., Rasmussen A.K.I., Thomsen A.R., Mouritzen P., Høyer S., Borre M., Ørntoft T.F., Sørensen K.D. (2018) Diagnostic and prognostic microRNA biomarkers for prostate cancer in cell-free urine. Eur. Urol. Focus, 4(6), 825–833. CrossRef Scholar google search
Fredsøe J., Rasmussen A.K.I., Mouritzen P., Borre M., Ørntoft T., Sørensen K.D. (2019) A five-microRNA model (pCaP) for predicting prostate cancer aggressiveness using cell-free urine. Int. J. Cancer, 145(9), 2558–2567. CrossRef Scholar google search
Siegel R.L., Miller K.D., Jemal A. (2018) Cancer statistics, 2018. CA Cancer J. Clin., 68(1), 7–30. CrossRef Scholar google search
Yodkhunnatham N., Pandit K., Puri D., Yuen K.L., Bagrodia A. (2024) MicroRNAs in testicular germ cell tumors: The teratoma challenge. Int. J. Mol. Sci., 25(4), 2156. CrossRef Scholar google search
King J., Kawakami J., Heng D., Gan C.L. (2020) Post-chemotherapy retroperitoneal lymph node dissection for non-seminomatous germ cell tumors: A single-surgeon, Canadian experience. Can. Urol. Assoc. J., 14(9), e407-e411. CrossRef Scholar google search
Zeuschner P., Linxweiler J., Junker K. (2020) Non-coding RNAs as biomarkers in liquid biopsies with a special emphasis on extracellular vesicles in urological malignancies. Expert. Rev. Mol. Diagn., 20(2), 151–167. CrossRef Scholar google search
Syring I., Bartels J., Holdenrieder S., Kristiansen G., Muller S.C., Ellinger J. (2015) Circulating serum miRNA (miR-367-3p, miR-371a-3p, miR-372-3p and miR-373-3p) as biomarkers in patients with testicular germ cell cancer. J. Urology, 193(1), 331–337. CrossRef Scholar google search
Dieckmann K.P., Radtke A., Spiekermann M., Balks T., Matthies C., Becker P., Ruf C., Oing C., Oechsle K., Bokemeyer C., Hammel J., Melchior S., Wosniok W., Belge G. (2017) Serum levels of microRNA miR-371a-3p: A sensitive and specific new biomarker for germ cell tumours. Eur. Urol., 71(2), 213–220. CrossRef Scholar google search
Leao R., van Agthoven T., Figueiredo A., Jewett M.A.S., Fadaak K., Sweet J., Fadaak K., Sweet J., Ahmad A.E., Anson-Cartwright L., Chung P., Hansen A., Warde P., Castelo-Branco P., O'Malley M., Bedard P.L., Looijenga L.H.J., Hamilton R.J. (2018) Serum miRNA predicts viable disease after chemotherapy in patients with testicular nonseminoma germ cell tumor. J. Urol., 200(1), 126–135. CrossRef Scholar google search
Terbuch A., Adiprasito J.B., Stiegelbauer V., Seles M., Klec C., Pichler G.P., Resel M., Posch F., Lembeck A.L., Stöger H., Szkandera J., Pummer K., Bauernhofer T., Hutterer G.C., Gerger A., Stotz M., Pichler M. (2018) MiR-371a-3p serum levels are increased in recurrence of testicular germ cell tumor patients. Int. J. Mol. Sci., 19(10), 3130. CrossRef Scholar google search
Shen H., Shih J., Hollern D.P., Wang L., Bowlby R., Tickoo S.K., Thorsson V., Mungall A.J., Newton Y., Hegde A.M., Armenia J., Sánchez-Vega F., Pluta J., Pyle L.C., Mehra R., Reuter V.E., Godoy G., Jones J., Shelley C.S., Feldman D.R., Vidal D.O., Lessel D., Kulis T., Cárcano F.M., Leraas K.M., Lichtenberg T.M., Brooks D., Cherniack A.D., Cho J., Heiman D.I., Kasaian K., Liu M., Noble M.S., Xi L., Zhang H., Zhou W., ZenKlusen J.C., Hutter C.M., Felau I., Zhang J., Schultz N., Getz G., Meyerson M., Stuart J.M., Akbani R., Wheeler D.A., Laird P.W., Nathanson K.L., Cortessis V.K., Hoadley K.A. (2018) Integrated molecular characterization of testicular germ cell tumors. Cell. Rep., 23(11), 3392–3406. CrossRef Scholar google search
Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 71(3), 209–249. CrossRef Scholar google search
Jayson G.C., Kohn E.C., Kitchener H.C., Ledermann J.A. (2014) Ovarian cancer. Lancet, 384(9951), 1376–1388. CrossRef Scholar google search
Prat J. (2015) Pathology of cancers of the female genital tract. Int. J. Gynaecol. Obstet., 131(Suppl 2), 132–145. CrossRef Scholar google search
Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. (2015) Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer, 136(5), 359–386. CrossRef Scholar google search
Siegel R.L., Miller K.D., Jemal A. (2017) Cancer Statistics, 2017. CA Cancer J. Clin., 67(1), 7–30. CrossRef Scholar google search
van Gorp T., Cadron I., Despierre E., Daemen A., Leunen K., Amant F., Timmerman D., de Moor B., Vergote I. (2011) HE4 and CA125 as a diagnostic test in ovarian cancer: Prospective validation of the risk of ovarian malignancy algorithm. Br. J. Cancer, 104(5), 863–870. CrossRef Scholar google search
Zhang M., Cheng S., Jin Y., Zhao Y., Wang Y. (2021) Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer. Biochim. Biophys. Acta Rev. Cancer, 1875(2), 188503. CrossRef Scholar google search
Kamal R., Hamed S., Mansour S., Mounir Y., Abdel Sallam S. (2018) Ovarian cancer screening-ultrasound; Impact on ovarian cancer mortality. Br. J. Radiol., 91(1090), 20170571. CrossRef Scholar google search
Nakamura K., Sawada K., Yoshimura A., Kinose Y., Nakatsuka E., Kimura T. (2016) Clinical relevance of circulating cell-free microRNAs in ovarian cancer. Mol. Cancer, 15(1), 48. CrossRef Scholar google search
Robotti M., Scebba F., Angeloni D. (2023) Circulating biomarkers for cancer detection: Could salivary microRNAs be an opportunity for ovarian cancer diagnostics? Biomedicines, 11(3), 652. CrossRef Scholar google search
Berner K., Hirschfeld M., Weiß D., Rücker G., Asberger J., Ritter A., Nöthling C., Jäger M., Juhasz-Böss I., Erbes T. (2022) Evaluation of circulating microRNAs as non-invasive biomarkers in the diagnosis of ovarian cancer: A case-control study. Arch. Gynecol. Obstet., 306(1), 151–163. CrossRef Scholar google search
Záveský L., Jandáková E., Turyna R., Langmeierová L., Weinberger V., Záveská Drábková L., Hůlková M., Hořínek A., Dušková D., Feyereisl J., Minář L., Kohoutová M. (2015) Evaluation of cell-free urine microRNAs expression for the use in diagnosis of ovarian and endometrial cancers. A pilot study. Pathol. Oncol. Res., 21(4), 1027–1035. CrossRef Scholar google search
Zhou J., Gong G., Tan H., Dai F., Zhu X., Chen Y., Wang J., Liu Y., Chen P., Wu X., Wen J. (2015) Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma. Oncol. Rep., 33(6), 2915–2923. CrossRef Scholar google search
Robin T.P., Amini A., Schefter T.E., Behbakht K., Fisher C.M. (2016) Disparities in standard of care treatment and associated survival decrement in patients with locally advanced cervical cancer. Gynecol. Oncol., 143(2), 319–325. CrossRef Scholar google search
Koh W.J., Abu-Rustum N.R., Bean S., Bradley K., Campos S.M., Cho K.R., Chon H.S., Chu C., Clark R., Cohn D., Crispens M.A., Damast S., Dorigo O., Eifel P.J., Fisher C.M., Frederick P., Gaffney D.K., Han E., Huh W.K., Lurain J.R., Mariani A., Mutch D., Nagel C., Nekhlyudov L., Fader A.N., Remmenga S.W., Reynolds R.K., Tillmanns T., Ueda S., Wyse E., Yashar C.M., McMillian N.R., Scavone J.L. (2019) Cervical Cancer, version 3. 2019, NCCN clinical practice guidelines in oncology. J. Natl. Compr. Canc. Netw., 17, 64–84. CrossRef Scholar google search
He Y., Han S.B., Liu Y., Zhang J.J., Wu Y.M. (2022) Role of APOA1 in the resistance to platinum-based chemotherapy in squamous cervical cancer. BMC Cancer, 22(1), 411. CrossRef Scholar google search
Demarco M., Lorey T.S., Fetterman B., Cheung L.C., Guido R.S., Wentzensen N., Kinney W.K., Poitras N.E., Befano B., Castle P.E., Schiffman M. (2017) Risks of CIN 2+, CIN 3+, and cancer by cytology and human papillomavirus status: The foundation of risk-based cervical screening guidelines. J. Low Genit. Tract. Dis., 21(4), 261–267. CrossRef Scholar google search
Charakorn C., Thadanipon K., Chaijindaratana S., Rattanasiri S., Numthavaj P., Thakkinstian A. (2018) The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: A systematic review and meta-analysis. Gynecol. Oncol., 150(1), 190–200. CrossRef Scholar google search
Jantharapattana K., Kotamnivates T., Hirunpat S., Jarumanokul R. (2018) Correlation between serum squamous cell carcinoma antigen level and tumor volume in head and neck cancer. ORL J. Otorhinolaryngol. Relat. Spec., 80(5–6), 284–289. CrossRef Scholar google search
Yuan C., Yang K., Tang H., Chen D. (2016) Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/oropharyngeal squamous cell carcinoma. Onco. Targets Ther., 9, 3381–3386. CrossRef Scholar google search
Kulpa J., Wójcik E., Radkowski A., Kolodziejski L., Stasik Z. (2000) CYFRA 21-1, TPA-M, TPS, SCC-Ag and CEA in patients with squamous cell lung cancer and in chemical industry workers as a reference group. Anticancer Res., 20(6D), 5035–5040. PMID: 11326663. Scholar google search
Nascimento N.P.G., Gally T.B., Borges G.F., Campos L.C.G., Kaneto C.M. (2022) Systematic review of circulating microRNAs as biomarkers of cervical carcinogenesis. BMC Cancer, 22(1), 862. CrossRef Scholar google search
Aftab M., Poojary S.S., Seshan V., Kumar S., Agarwal P., Tandon S., Zutshi V., Das B.C. (2021) Urine miRNA signature as a potential non-invasive diagnostic and prognostic biomarker in cervical cancer. Sci. Rep., 11(1), 10323. CrossRef Scholar google search
