Molecular mechanisms of the regulatory action of high-density lipoproteins on the endothelial function

  
Poteryaeva O.N.1 , Usynin I.F.1

1. Institute of Biochemistry, Federal Research Center of Fundamental and Translation Medicine, Novosibirsk, Russia
Section: Review
DOI: 10.18097/PBMC20247004206      PubMed Id: 39239895
Year: 2024  Volume: 70  Issue: 4  Pages: 206-217
Endothelial dysfunction underlies the pathogenesis of many diseases, primarily cardiovascular diseases. Epidemiological studies have shown an inverse dependence between the plasma level of high-density lipoproteins (HDL) and cardiovascular diseases. The results of experimental studies indicate that the antiatherogenic effect of HDL is associated not only with their participation in the reverse transport of excess cholesterol, but also with their regulatory effect on the functions of cells of various organs and tissues, including endothelial cells. The purpose of this review is to consider recent data on the participation of plasma receptors and related intracellular signaling pathways in the mechanism of protective effect of HDL on endothelial cell functions. Understanding the mechanisms of cell function regulation under the influence of HDL is an important step for the development of new ways of pharmacological correction of impaired endothelial functions and creation of effective endothelial protection drugs.
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Keywords: high density lipoproteins, apolipoprotein A-I, signaling pathways, endotelial dysfunction
Citation:

Poteryaeva, O. N., Usynin, I. F. (2024). Molecular mechanisms of the regulatory action of high-density lipoproteins on the endothelial function. Biomeditsinskaya Khimiya, 70(4), 206-217.
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