The review considers modern achievements and prospects of using nanowire biosensors, principles of their operation, methods of fabrication, and the influence of the Debye effect, which plays a key role in improving the biosensor characteristics. Special attention is paid to the practical application of such biosensors for the detection of a variety of biomolecules, demonstrating their capabilities and potential in the detection of a wide range of biomarkers of various diseases. Nanowire biosensors also show excellent results in such areas as early disease diagnostics, patient health monitoring, and personalized medicine due to their high sensitivity and specificity. Taking into consideration their high efficiency and diverse applications, nanowire-based biosensors demonstrate significant promise for commercialization and widespread application in medicine and related fields, making them an important area for future research and development.
Goldaeva K.V. et al. Nanowire-based biosensors for solving biomedical problems // Biomeditsinskaya Khimiya. - 2024. - V. 70. -N 5. - P. 304-314.
Goldaeva K.V. et al., "Nanowire-based biosensors for solving biomedical problems." Biomeditsinskaya Khimiya 70.5 (2024): 304-314.
Goldaeva, K. V., Pleshakova, T. O., Ivanov, Yu. D. (2024). Nanowire-based biosensors for solving biomedical problems. Biomeditsinskaya Khimiya, 70(5), 304-314.
References
Hsu C.-Y., Rheima A.M., Abbas Z.S., Faryad M.U., Kadhim M.M., Altimari U.S., Dawood A.H., Jawad Al-Bayati A.D., Abed Z.T., Radhi R.S., Jaber A.S., Hachim S.K., Ali F.K., Mahmoud Z.H., Behzadi Pour G., Kianfar E. (2023) Nanowires properties and applications: A review study. S. Afr. J. Chem. Eng., 46, 286–311. CrossRef Scholar google search
Mim J.J., Hasan M., Chowdhury M.S., Ghosh J., Mobarak M.H., Khanom F., Hossain N. (2024) A comprehensive review on the biomedical frontiers of nanowire applications. Heliyon, 10(8), e29244. CrossRef Scholar google search
Seker F., Meeker K., Kuech T.F., Ellis A.B. (2000) Surface chemistry of prototypical bulk II-VI and III-V semiconductors and implications for chemical sensing. Chem. Rev., 100(7), 2505–2536. CrossRef Scholar google search
Biosensor AN. Retrieved July 10, 2024, from: http://biosensoran.ru/. Scholar google search
TB-Biochip. Retrieved July 10, 2024, from: http://www.biochip.ru/lab/apps/tb-biochip.html. Scholar google search
Rusens Ltd. Retrieved July 10, 2024, from: http://rusens.com/. Scholar google search
Ivanov Y.D., Malsagova K.A., Popov V.P., Kupriyanov I.N., Pleshakova T.O., Galiullin R.A., Ziborov V.S., Dolgoborodov A.Y., Petrov O.F., Miakonkikh A.V., Rudenko K.V., Glukhov A.V., Smirnov A.Y., Usachev D.Y., Gadzhieva O.A., Bashiryan B.A., Shimansky V.N., Enikeev D.V., Potoldykova N.V., Archakov A.I. (2021) Micro-raman characterization of structural features of high-k stack layer of SOI nanowire chip, designed to detect circular RNA associated with the development of glioma. Molecules, 26(12), 3715. CrossRef Scholar google search
Ivanov Y.D., Malsagova K.A., Goldaeva K.V., Pleshakova T.O., Shumov I.D., Galiullin R.A., Kapustina S.I., Iourov I.Y., Vorsanova S.G., Ryabtsev S.V., Popov V.P., Archakov A.I. (2022) “Silicon-on-insulator”-based nanosensor for the revelation of microRNA markers of autism. Genes, 13(2), 199. CrossRef Scholar google search
Malsagova K.A., Pleshakova T.O., Galiullin R.A., Kozlov A.F., Shumov I.D., Popov V.P., Tikhonenko F.V., Glukhov A.V., Ziborov V.S., Petrov O.F., Fortov V.E., Archakov A.I., Ivanov Y.D. (2020) Highly sensitive detection of CA 125 protein with the use of an n-type nanowire biosensor. Biosensors, 10(12), 210. CrossRef Scholar google search
Ivanov Y.D., Goldaeva K.V., Malsagova K.A., Pleshakova T.O., Galiullin R.A., Popov V.P., Kushlinskii N.E., Alferov A.A., Enikeev D.V., Potoldykova N.V., Archakov A.I. (2021) Nanoribbon biosensor in the detection of miRNAs associated with colorectal cancer. Micromachines, 12(12), 1581. CrossRef Scholar google search
Presnov D.E., Amitonov S.V., Krutitskii P.A., Kolybasova V.V., Devyatov I.A., Krupenin V.A., Soloviev I.I. (2013) A highly pH-sensitive nanowire field-effect transistor based on silicon on insulator. Beilstein J. Nanotechnol., 4, 330–335. CrossRef Scholar google search
Dmitrienko E., Naumova O., Fomin B., Kupryushkin M., Volkova A., Amirkhanov N., Semenov D., Pyshnaya I., Pyshnyi D. (2016) Surface modification of SOI-FET sensors for label-free and specific detection of short RNA analyte. Nanomedicine (London), 11(16), 2073–2082. CrossRef Scholar google search
Cui Y., Duan X., Hu J., Lieber C.M. (2000) Doping and electrical transport in silicon nanowires. J. Phys. Chem. B, 104(22), 5213–5216. CrossRef Scholar google search
Sun B., Shao M., Lee S. (2016) Nanostructured silicon used for flexible and mobile electricity generation. Adv. Mater., 28(47), 10539–10547. CrossRef Scholar google search
Dasgupta N.P., Sun J., Liu C., Brittman S., Andrews S.C., Lim J., Gao H., Yan R., Yang P. (2014) 25th anniversary article: Semiconductor nanowires — synthesis, characterization, and applications. Adv. Mater., 26(14), 2137–2184. CrossRef Scholar google search
Li X., Mo J., Fang J., Xu D., Yang C., Zhang M., Li H., Xie X., Hu N., Liu F. (2020) Vertical nanowire array-based biosensors: Device design strategies and biomedical applications. J. Mater. Chem. B, 8(34), 7609–7632. CrossRef Scholar google search
Adam T., Dhahi T.S., Gopinath S.C.B., Hashim U. (2022) Novel approaches in fabrication and integration of nanowire for micro/nano systems. Crit. Rev. Anal. Chem., 52(8), 1913–1929. CrossRef Scholar google search
Zhang H., Kikuchi N., Ohshima N., Kajisa T., Sakata T., Izumi T., Sone H. (2020) Design and fabrication of silicon nanowire-based biosensors with integration of critical factors: Toward ultrasensitive specific detection of biomolecules. ACS Appl. Mater. Interfaces, 12(46), 51808–51819. CrossRef Scholar google search
Rouis A., Hizem N., Hassen M., Kalboussi A. (2022) Electrical properties of silicon nanowires Schottky barriers prepared by MACE at different etching time. Silicon, 14(9), 4731–4737. CrossRef Scholar google search
Poghossian A., Cherstvy A., Ingebrandt S., Offenhäusser A., Schöning M.J. (2005) Possibilities and limitations of label-free detection of DNA hybridization with field-effect-based devices. Sens. Actuators B Chem., 111–112, 470–480. CrossRef Scholar google search
Woo J.-M., Kim S.H., Chun H., Kim S.J., Ahn J., Park Y.J. (2013) Modulation of molecular hybridization and charge screening in a carbon nanotube network channel using the electrical pulse method. Lab Chip, 13(18), 3755. CrossRef Scholar google search
Kim K.S., Lee H.-S., Yang J.-A., Jo M.-H., Hahn S.K. (2009) The fabrication, characterization and application of aptamer-functionalized Si-nanowire FET biosensors. Nanotechnology, 20(23), 235501. CrossRef Scholar google search
Stern E., Wagner R., Sigworth F.J., Breaker R., Fahmy T.M., Reed M.A. (2007) Importance of the Debye screening length on nanowire field effect transistor sensors. Nano Lett., 7(11), 3405–3409. CrossRef Scholar google search
Zhang G.-J., Ning Y. (2012) Silicon nanowire biosensor and its applications in disease diagnostics: A review. Anal. Chim.Acta, 749, 1–15. CrossRef Scholar google search
Ramanujam J., Shiri D., Verma A. (2011) Silicon nanowire growth and properties: A review. Materials Express, 1(2), 105–126. CrossRef Scholar google search
Hobbs R.G., Petkov N., Holmes J.D. (2012) Semiconductor nanowire fabrication by bottom-up and top-down paradigms. Chem. Mater., 24(11), 1975–1991. CrossRef Scholar google search
Wang F., Dong A., Buhro W.E. (2016) Solution-liquid-solid synthesis, properties, and applications of one-dimensional colloidal semiconductor nanorods and nanowires. Chem. Rev., 116(18), 10888–10933. CrossRef Scholar google search
Alam S.B., Panciera F., Hansen O., Mølhave K., Ross F.M. (2015) Creating new VLS silicon nanowire contact geometries by controlling catalyst migration. Nano Lett., 15(10), 6535–6541. CrossRef Scholar google search
Tintelott M., Pachauri V., Ingebrandt S., Vu X.T. (2021) Process variability in top-down fabrication of silicon nanowire-based biosensor arrays. Sensors, 21(15), 5153. CrossRef Scholar google search
Elbersen R., Vijselaar W., Tiggelaar R.M., Gardeniers H., Huskens J. (2015) Fabrication and doping methods for silicon nano- and micropillar arrays for solar-cell applications: A review. Adv. Mater., 27(43), 6781–6796. CrossRef Scholar google search
Mohd Azmi M.A., Tehrani Z., Lewis R.P., Walker K.-A.D., Jones D.R., Daniels D.R., Doak S.H., Guy O.J. (2014) Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker. Biosens. Bioelectron., 52, 216–224. CrossRef Scholar google search
Park I., Li Z., Pisano A.P., Williams R.S. (2010) Top-down fabricated silicon nanowire sensors for real-time chemical detection. Nanotechnology, 21(1), 015501. CrossRef Scholar google search
Li D., Chen H., Fan K., Labunov V., Lazarouk S., Yue X., Liu C., Yang X., Dong L., Wang G. (2021) A supersensitive silicon nanowire array biosensor for quantitating tumor marker ctDNA. Biosens. Bioelectron., 181, 113147. CrossRef Scholar google search
Hu J., Li Y., Zhang X., Wang Y., Zhang J., Yan J., Li J., Zhang Z., Yin H., Wei Q., Jiang Q., Wei S., Zhang Q. (2023) Ultrasensitive silicon nanowire biosensor with modulated threshold voltages and ultra-small diameter for early kidney failure biomarker cystatin C. Biosensors, 13(6), 645. CrossRef Scholar google search
Zhu Y., Wei Q., Jin Q., Li G., Zhang Q., Xiao H., Li T., Wei F., Luo Y. (2023) Polyethylene glycol functionalized silicon nanowire field-effect transistor biosensor for glucose detection. Nanomaterials, 13(3), 604. CrossRef Scholar google search
Gao B., Rojas Chavez A.A., Malkawi W.I., Keefe D.W., Smith R., Haim H., Salem A.K., Toor F. (2022) Sensitive detection of SARS-CoV-2 spike protein using vertically-oriented silicon nanowire array-based biosensor. Sens. Bio-Sens. Res., 36, 100487. CrossRef Scholar google search
Lee J.-H., Chae E.-J., Park S.-J., Choi J.-W. (2019) Label-free detection of γ-aminobutyric acid based on silicon nanowire biosensor. Nano Convergence, 6(1), 13. CrossRef Scholar google search
Yang X., Fan Y., Wu Z., Liu C. (2019) A silicon nanowire array biosensor fabricated by complementary metal oxide semiconductor technique for highly sensitive and selective detection of serum carcinoembryonic antigen. Micromachines, 10(11), 764. CrossRef Scholar google search
Presnova G., Presnov D., Krupenin V., Grigorenko V., Trifonov A., Andreeva I., Ignatenko O., Egorov A., Rubtsova M. (2017) Biosensor based on a silicon nanowire field-effect transistor functionalized by gold nanoparticles for the highly sensitive determination of prostate specific antigen. Biosens. Bioelectron., 88, 283–289. CrossRef Scholar google search
Abd Rahman S.F., Yusof N.A., Md Arshad M.K., Hashim U., Md Nor M.N., Hamidon M.N. (2022) Fabrication of silicon nanowire sensors for highly sensitive pH and DNA hybridization detection. Nanomaterials, 12(15), 2652. CrossRef Scholar google search
Yong S.K., Shen S.-K., Chiang C.-W., Weng Y.-Y., Lu M.-P., Yang Y.-S. (2021) Silicon nanowire field-effect transistor as label-free detection of hepatitis B virus proteins with opposite net charges. Biosensors, 11(11), 442. CrossRef Scholar google search
Vu C.-A., Lai H.-Y., Chang C.-Y., Chan H.W.-H., Chen W.-Y. (2022) Optimizing surface modification of silicon nanowire field-effect transistors by polyethylene glycol for microRNA detection. Colloids Surf. B Biointerfaces, 209(Pt 1), 112142. CrossRef Scholar google search
Lu K., Liu C., Wang G., Yang W., Fan K., Lazarouk S., Labunov V., Dong L., Li D., Yang X. (2022) A highly sensitive silicon nanowire array sensor for joint detection of tumor markers CEA and AFP. Biomater. Sci., 10(14), 3823–3830. CrossRef Scholar google search
Hu W.-P., Wu Y.-M., Vu C.-A., Chen W.-Y. (2023) Ultrasensitive detection of interleukin 6 by using silicon nanowire field-effect transistors. Sensors, 23(2), 625. CrossRef Scholar google search
Benserhir Y., Salaün A.-C., Geneste F., Oliviero N., Pichon L., Jolivet-Gougeon A. (2022) Silicon nanowires-based biosensors for the electrical detection of Escherichia coli. Biosens. Bioelectron., 216, 114625. CrossRef Scholar google search
Chang S.-M., Palanisamy S., Wu T.-H., Chen C.-Y., Cheng K.-H., Lee C.-Y., Yuan S.-S.F., Wang Y.-M. (2020) Utilization of silicon nanowire field-effect transistors for the detection of a cardiac biomarker, cardiac troponin I and their applications involving animal models. Sci. Rep., 10(1), 22027. CrossRef Scholar google search
Li H., Wang S., Li X., Cheng C., Shen X., Wang T. (2022) Dual-channel detection of breast cancer biomarkers CA15-3 and CEA in human serum using dialysis-silicon nanowire field effect transistor. Int. J. Nanomedicine, 17, 6289–6299. CrossRef Scholar google search
Ma J., Du M., Wang C., Xie X., Wang H., Li T., Chen S., Zhang L., Mao S., Zhou X., Wu M. (2021) Rapid and sensitive detection of Mycobacterium tuberculosis by an enhanced nanobiosensor. ACS Sens., 6(9), 3367–3376. CrossRef Scholar google search
Wei S., Dou Y., Yu Y., Yang J., Yu F., Sha W., Li T. (2023) A novel biosensor based on a bio-barcode for the detection of Mycobacterium tuberculosis. Anal. Methods, 15(30), 3683–3691. CrossRef Scholar google search
Wu C.-C. (2022) Silicon nanowires length and numbers dependence on sensitivity of the field-effect transistor sensor for hepatitis B virus surface antigen detection. Biosensors, 12(2), 115. CrossRef Scholar google search
Li H.-J., Zhi S., Zhang S., Guo X., Huang Y., Xu L., Wang X., Wang D., Zhu M., He B. (2022) A novel photoelectrochemical sensor based on SiNWs@PDA for efficient detection of myocardial infarction. Biomater. Sci., 10(16), 4627–4634. CrossRef Scholar google search
Gao A., Yang X., Tong J., Zhou L., Wang Y., Zhao J., Mao H., Li T. (2017) Multiplexed detection of lung cancer biomarkers in patients serum with CMOS-compatible silicon nanowire arrays. Biosens. Bioelectron., 91, 482–488. CrossRef Scholar google search
Singh R., Chack D., Priye V. (2022) SNROW-based highly sensitive label-free surface biosensor for hepatitis B detection. Appl. Opt., 61(22), 6510–6517. CrossRef Scholar google search
Lee M., Palanisamy S., Zhou B.-H., Wang L.-Y., Chen C.-Y., Lee C.-Y., Yuan S.-S.F., Wang Y.-M. (2018) Ultrasensitive electrical detection of follicle-stimulating hormone using a functionalized silicon nanowire transistor chemosensor. ACS Appl. Mater. Interfaces, 10(42), 36120–36127. CrossRef Scholar google search
Uhm M., Lee J.-M., Lee J., Lee J.H., Choi S., Park B.-G., Kim D.M., Choi S.-J., Mo H.-S., Jeong Y.-J., Kim D.H. (2019) Ultrasensitive electrical detection of hemagglutinin for point-of-care detection of influenza virus based on a CMP-NANA probe and top-down processed silicon nanowire field-effect transistors. Sensors, 19(20), 4502. CrossRef Scholar google search
Ivanov Y., Pleshakova T., Malsagova K., Kurbatov L., Popov V., Glukhov A., Smirnov A., Enikeev D., Potoldykova N., Alekseev B., Dolotkazin D., Kaprin A., Ziborov V., Petrov O., Archakov A. (2019) Detection of marker miRNAs, associated with prostate cancer, in plasma using SOI-NW biosensor in direct and inversion modes. Sensors, 19(23), 5248. CrossRef Scholar google search
Leonardi A.A., Sciuto E.L., Lo Faro M.J., Fazio B., Rizzo M.G., Calabrese G., Francioso L., Picca R., Nastasi F., Mancuso G., Spinella C., Knoll W., Irrera A., Conoci S. (2022) SARS-CoV-2 and omicron variant detection with a high selectivity, sensitivity, and low-cost silicon bio-nanosensor. Nano Select, 4(2), 160–169. CrossRef Scholar google search
Li H.-J., Huang Y., Zhang S., Chen C., Guo X., Xu L., Liao Q., Xu J., Zhu M., Wang X., Wang D., He B. (2023) S-Scheme porphyrin covalent organic framework heterojunction for boosted photoelectrochemical immunoassays in myocardial infarction diagnosis. ACS Sens., 8(5), 2030–2040. CrossRef Scholar google search
Pandey R.R., Alshahrani H.S., Krylyuk S., Williams E.H., Davydov A.V., Chusuei C.C. (2018) Electrochemical detection of acetaminophen with silicon nanowires. Electroanalysis, 30(5), 886–891. CrossRef Scholar google search
Geka G., Kanioura A., Kochylas I., Likodimos V., Gardelis S., Dimitriou A., Papanikolaou N., Chatzantonaki K., Charvalos E., Economou A., Kakabakos S., Petrou P. (2023) Cancer marker immunosensing through surface-enhanced photoluminescence on nanostructured silver substrates. Nanomaterials, 13(24), 3099. CrossRef Scholar google search
Malsagova K.A., Pleshakova T.O., Kozlov A.F., Shumov I.D., Ilnitskii M.A., Miakonkikh A.V., Popov V.P., Rudenko K.V., Glukhov A.V., Kupriyanov I.N., Ivanova N.D., Rogozhin A.E., Archakov A.I., Ivanov Y.D. (2018) Micro-raman spectroscopy for monitoring of deposition quality of high-k stack protective layer onto nanowire FET chips for highly sensitive miRNA detection. Biosensors, 8(3), 72. CrossRef Scholar google search
Leonardi A.A., Battaglia R., Morganti D., Lo Faro M.J., Fazio B., de Pascali C., Francioso L., Palazzo G., Mallardi A., Purrello M., Priolo F., Musumeci P., di Pietro C., Irrera A. (2021) A novel silicon platform for selective isolation, quantification, and molecular analysis of small extracellular vesicles. Int. J. Nanomedicine, 16, 5153–5165. CrossRef Scholar google search
Malsagova K.A., Pleshakova T.O., Kozlov A.F., Galiullin R.A., Popov V.P., Tikhonenko F.V., Glukhov A.V., Ziborov V.S., Shumov I.D., Petrov O.F., Generalov V.M., Cheremiskina A.A., Durumanov A.G., Agafonov A.P., Gavrilova E.V., Maksyutov R.A., Safatov A.S., Nikitaev V.G., Pronichev A.N., Konev V.A., Archakov A.I., Ivanov Y.D. (2021) Detection of influenza virus using a SOI-nanoribbon chip, based on an n-type field-effect transistor. Biosensors, 11(4), 119. CrossRef Scholar google search
Kanioura A., Geka G., Kochylas I., Likodimos V., Gardelis S., Dimitriou A., Papanikolaou N., Kakabakos S., Petrou P. (2023) SERS determination of oxidative stress markers in saliva using substrates with silver nanoparticle-decorated silicon nanowires. Biosensors, 13(2), 273. CrossRef Scholar google search
Rani D., Singh Y., Salker M., Vu X.T., Ingebrandt S., Pachauri V. (2020) Point-of-care-ready nanoscale ISFET arrays for sub-picomolar detection of cytokines in cell cultures. Anal. Bioanal. Chem., 412(25), 6777–6788. CrossRef Scholar google search
Xu S., Wang G., Feng Y., Zheng J., Huang L., Liu J., Jiang Y., Wang Y., Liu N. (2024) PNA-functionalized, silica nanowires-filled glass microtube for ultrasensitive and label-free detection of miRNA-21. Anal. Chem., 96(19), 7470–7478. CrossRef Scholar google search
Kouz S., Raouafi A., Ouhibi A., Lorrain N., Essafi M., Mejri M., Raouafi N., Moadhen A., Guendouz M. (2024) Detection of SARS-CoV-2 N protein using AgNPs-modified aligned silicon nanowires BioSERS chip. RSC Adv., 14(17), 12071–12080. CrossRef Scholar google search
Leonardi A.A., Lo Faro M.J., Petralia S., Fazio B., Musumeci P., Conoci S., Irrera A., Priolo F. (2018) Ultrasensitive label- and PCR-free genome detection based on cooperative hybridization of silicon nanowires optical biosensors. ACS Sens., 3(9), 1690–1697. CrossRef Scholar google search
Lee S.-W., Chen Y.-W., Kuan E.C., Lan M.-Y. (2019) Dual-function nanostructured platform for isolation of nasopharyngeal carcinoma circulating tumor cells and EBV DNA detection. Biosens. Bioelectron., 142, 111509. CrossRef Scholar google search
