Prediction of the course of chronic obstructive pulmonary disease by blood biomarkers

  
Murashka D.I.1 , Tahanovich A.D.1, Kauhanka M.M.1, Nikitina I.A.1, Kolb A.V.1, Bogush L.S.2, Davidovskaya E.I.2, Budnik O.A.2

1. Belarusian State Medical University, Minsk, Belarus
2. Republican Scientific and Practical Center of Pulmonology and Phthisiatry, Minsk, Belarus
Section: Review
DOI: 10.18097/PBMCR1579      PubMed Id: 40904178
Year: 2025  Volume: 71  Issue: 4  Pages: 256-269
Chronic obstructive pulmonary disease (COPD) is one of the most common pathologies of the respiratory system; it is characterized by increasing airflow limitation. The course of COPD is unstable and is often accompanied by periods of exacerbation, when respiratory symptoms of the disease significantly increase. The frequency of COPD exacerbations is an important predictor of its course, allowing to predict the decline in lung tissue function and the outcome of the disease. Currently, the risk of future COPD exacerbations in a patient is assessed based on the history of previous exacerbations, and the improvement of his condition is evaluated on the basis of the weakening of COPD symptoms. However, the lack of objective criteria complicates unambiguous verdict on the probability of acute condition development and the effectiveness of treatment of COPD patients. Based on the analysis of literature data we propose determination of the levels of chemokines (CXCL5, CXCL8, CXCR1/2, CD44v6), HIF-1α, procalcitonin, albumin and C-reactive protein, leukocyte cells, as well as their possible combination in the peripheral blood as an informative tool for evaluation in COPD patients.
Download PDF:  
Keywords: COPD, biomarkers, CXCL5, CXCL8, CXCR1/2, CD44v6, HIF-1α, acute phase proteins, blood cells
Citation:

Murashka, D. I., Tahanovich, A. D., Kauhanka, M. M., Nikitina, I. A., Kolb, A. V., Bogush, L. S., Davidovskaya, E. I., Budnik, O. A. (2025). Prediction of the course of chronic obstructive pulmonary disease by blood biomarkers. Biomeditsinskaya Khimiya, 71(4), 256-269.
References  
 2025 (vol 71)
 2024 (vol 70)
 2023 (vol 69)
 2022 (vol 68)
 2021 (vol 67)
 2020 (vol 66)
 2019 (vol 65)
 2018 (vol 64)
 2017 (vol 63)
 2016 (vol 62)
 2015 (vol 61)
 2014 (vol 60)
 2013 (vol 59)
 2012 (vol 58)
 2011 (vol 57)
 2010 (vol 56)
 2009 (vol 55)
 2008 (vol 54)
 2007 (vol 53)
 2006 (vol 52)
 2005 (vol 51)
 2004 (vol 50)
 2003 (vol 49)