Bioinformatic identification of proteins with varying levels of post-translational modifications in a model of atherogenesis in mice

  
Miroshnichenko Yu.V.1 , Rybina A.V.1, Skvortsov V.S.1

1. Institute of Biomedical Chemistry, Moscow, Russia
Section: Short Communication
DOI: 10.18097/PBMCR1575      PubMed Id: 40904183
Year: 2025  Volume: 71  Issue: 4  Pages: 308-313
Mass spectrometric data obtained using a model of tandem carotid artery stenosis in mice with unstable and stable atherosclerosis were analyzed to identify differences in the level of post-translational modifications (PTMs) of proteins. The original proteomic data obtained by Chen et al. [DOI: 10.1038/s42003-023-04641-4] and deposited in the PRIDE repository (identifier PXD030857) were used. Based on results of the bioinformatic analysis, 12 proteins with PTMs (methylation, acetylation, and phosphorylation) were selected; comparison of healthy and atherosclerotic vascular sections showed that the selected proteins were characterized by significant changes in the level of individual modified peptides. According to the literature data, all 12 proteins are involved in the process of atherogenesis. Our study thus revealed putative points of regulation of the atherogenesis processes at the PTM level.
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Keywords: post-translational modifications, atherosclerosis, bioinformatics
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Miroshnichenko, Yu. V., Rybina, A. V., Skvortsov, V. S. (2025). Bioinformatic identification of proteins with varying levels of post-translational modifications in a model of atherogenesis in mice. Biomeditsinskaya Khimiya, 71(4), 308-313.
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