1. Institute of Biomedical Chemistry, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia 2. Institute of Biomedical Chemistry, Moscow, Russia 3. Pirogov Russian National Research Medical University, Moscow, Russia
This literature review examines the biological properties of hyaluronic acid (HA), its various chemical modifications with carboxyl, hydroxyl, and acetamide groups, applicable in drug and genetic material delivery systems. Special attention is paid to the use of HA in complexes with metal nanoparticles, other biopolymers, and biomolecules. HA molecules of different molar masses exhibit different effects on cellular processes. Therefore, HA fractions with strictly defined molecular masses are used to achieve various goals. Unique properties of HAsuch as high bioavailability, biocompatibility, antioxidant properties, and high affinity for a number of cellular receptors make HA a promising means for use in targeted therapy. The use of HA in regenerative medicine has been also discussed.
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Keywords: hyaluronic acid, drug delivery systems, metal nanoparticles, antioxidant properties, aging, geroprotective properties
Shumyantseva V.V. et al. Hyaluronic acid: biochemical properties and medical applications // Biomeditsinskaya Khimiya. - 2026. - V. 72. -N 2. - P. 85-101.
Shumyantseva V.V. et al., "Hyaluronic acid: biochemical properties and medical applications." Biomeditsinskaya Khimiya 72.2 (2026): 85-101.
Shumyantseva, V. V., Agafonova, L. E., Filippova, T. A., Masamrekh, R. A., Khudoklinova, Yu. Yu., Kuzikov, A. V., Archakov, A. I. (2026). Hyaluronic acid: biochemical properties and medical applications. Biomeditsinskaya Khimiya, 72(2), 85-101.
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