Lymphocyte metabolism in patients with acute pancreatitis and different genotypes of GSTM1 and GSTT1 genes

   
Markova E.V.1 , Zotova N.V.1, Savchenko A.A.1, Titova N.M.1, Slepov E.V.1, Cherdancev D.V.2, Konovalenko A.N.2

1. Krasnoyarsk State University
2. Krasnoyarsk State Medical Academy
Section: Experimental/Clinical Study
PubMed Id: 16898590
Year: 2006  Volume: 52  Issue: 3  Pages: 317-326
In this study, we have investigated correlation between enzymatic activity of NAD(P)-dependent dehydrogenases of lymphocytes and polymorphic variants of glutathione S-transferase Ml (GSTM1) and T1 (GSTT1) genes in the group of unrelated patients with acute pancreatitis in comparison with healthy Russians from Krasnoyarsk. Thus, genotype GSTM1 0/0 is the marker of predisposition to the acute pancreatitis, wheras polymorphism of the GSTT1 gene is not involved in the development of the pancreatitis, at least in our group. The bioluminescence analysis showed statistically significant decrease of the levels of G3PD, NAD(+)MDH and the increase of NADH(+)LDH, NAD(+)GDH, NADH(+)GDH in lymphocytes of pancreatic group. Development of pancreatitis in patients with different genotypes GSTM1 and GSTT1 genes showed the rearrangement of the basic intracellular processes: dominance of a plastic metabolism in the patients with GSTM1 - deletions and predominance of energetic processes at GSTT1 0 - pancreatitis.
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Keywords: acute pancreatitis, metabolism lymphocytes, activity of NAD(P)-depended dehydrogenases, genetic polymorphism, GSTM1, GSTT1
Citation:

Markova, E. V., Zotova, N. V., Savchenko, A. A., Titova, N. M., Slepov, E. V., Cherdancev, D. V., Konovalenko, A. N. (2006). Lymphocyte metabolism in patients with acute pancreatitis and different genotypes of GSTM1 and GSTT1 genes. Biomeditsinskaya khimiya, 52(3), 317-326.
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