Perspectives of disodium salt 2.4-di(1-metoxyethyl)-deuteroporphyrin – IX (“dimegin”) application for photodynamic therapy in non-oncologic cases

Bondarenko V.M.1, Alexeev Yu.V.2, Mislavsky O.V.2, Ponomarev G.V.3

1. Gamaleya Reserch Institute of Epidemiology and Microbiology RAMS
2. State Reserch and Clinical Center for Laser Medicine
3. Russian Academy of Medical Science, Institute of Biomedical Chemistry, RAMS
Section: Experimental Study
DOI: 10.18097/pbmc20146003338      UDK: 616-035.1      PubMed Id: 25019396
Year: 2014  Volume: 60  Issue: 3  Pages: 338-347
Effects of disodium salt 2,4-di(1-metoxyethyl)-deuteroporphyrine-IX (Dimegin) and the light from Soret band (»395-405 nm) at the viability of microbial cells and at their potential to form microbial biofilms have been compared with traditional antiseptics. Irradiation of microbial cells of S. aureus, E. coli, C. albicans and others with diode light (power density 0.05 Wt/cm2) caused a bactericidial effect similar to that obtained with standard anticeptics (chlorhexidine and dioxidine). A comparative study of the effectiveness of Dimegin and Photoditazine (a soluble salt of chlorine e6) as photosensitizers have been performed using the test system of erythrocyte hemolysis in vitro under irradiation with light from the Sore band. Results have shown insignificant difference in the photodynamic effect with similar doses of absorbed light and preparation concentration.
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Bondarenko V.M., Alexeev Yu.V., Mislavsky O.V., Ponomarev G.V. (2014) Biomeditsinskaya khimiya, 60(3), 338-347.
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