Secondary metabolites of plants and their possible role in the “age of superbugs”

Nesterovich V.M.1, Belykh D.A.1, Gorokhovets N.V.1, Kurbatov L.K.2, Zamyatnin A.A.3, Ikryannikova L.N.1

1. Sechenov University, Moscow, Russia
2. Tyumen State University, Tyumen, Russia
3. Sechenov University, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia
Section: Review
DOI: 10.18097/PBMC20236906371      PubMed Id: 38153052
Year: 2023  Volume: 69  Issue: 6  Pages: 371-382
Bacterial infections are a serious cause of high morbidity and mortality worldwide. Over the past decades, the drug resistance of bacterial pathogens has been steadily increasing, while the rate of development of new effective antibacterial drugs remains consistently low. The plant kingdom is sometimes called a bottomless well for the search for new antimicrobial therapies. This is due to the fact that plants are easily accessible and cheap to process, while extracts and components of plant origin often demonstrate a high level of biological activity with minor side effects. The variety of compounds obtained from plant raw materials can provide a wide choice of various chemical structures for interaction with various targets inside bacterial cells, while the rapid development of modern biotechnological tools opens the way to the targeted production of bioactive components with desired properties. The objective of this review is to answer the question, whether antimicrobials of plant origin have a chance to play the role of a panacea in the fight against infectious diseases in the “post-antibiotic era”.
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Keywords: secondary metabolites of plants, phyto metabolites, drug resistance, bacterial pathogens, antimicrobial properties

Nesterovich, V. M., Belykh, D. A., Gorokhovets, N. V., Kurbatov, L. K., Zamyatnin, A. A., Ikryannikova, L. N. (2023). Secondary metabolites of plants and their possible role in the “age of superbugs”. Biomeditsinskaya Khimiya, 69(6), 371-382.
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