VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Self-regulation of the functional state of high density lipoproteins and its disorders in hypoalphacholesterolemia (review)

   
Gerasimova E.N., Perova N.V.
PubMed Id: 3885566
Year: 1985  Volume: 31  Issue: 1  Pages: 32-40
Cholesterol-acceptor and cholesterol-transport functions of high density lipoproteins appear to occur by means of the principle of selfregulation as these lipoproteins (particles) included a number of active units responsible for their biological function. These units were as follows: a) protein-lipid structure of surface monolayer of high density lipoprotein particles, which enables to intercalate the molecules of unesterified cholesterol, b) the enzymatic system, responsible for cholesterol esterification (lecithin-cholesterol acyltransferase--LCAT), involving the enzyme second substrate lecithin and activator apoprotein A-1, c) the system of nonenzymatic controlled transport of cholesterol esters, developed during the LCAT-reaction, involving the lipid-transport protein. On the basis of the hypothesis results, obtained in examination of persons with low and high level of high density lipoprotein cholesterol in blood plasma, were analyzed. Correlation between a decrease in cholesterol-acceptor and -transport functions of the lipoproteins and impairments in the system, responsible for selfregulation of their functional state, corroborated the hypothesis developed.
Download PDF:  
Citation:

Gerasimova, E. N., Perova, N. V. (1985). Self-regulation of the functional state of high density lipoproteins and its disorders in hypoalphacholesterolemia (review). Voprosy Meditsinskoi Khimii, 31(1), 32-40.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
◄        ►