VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Role of sialic acid loss in the myocardium in depressing the contractile function of the heart muscle during stress

   
Meerson F.Z., Saulia A.I., Gudumak V.S.
PubMed Id: 3873749
Year: 1985  Volume: 31  Issue: 2  Pages: 118-120
Under conditions of stress a time-dependent decrease in content of sialic acids was found in adult rats; within 9 hrs of the animal immobilization the sialic acid content was decreased by 40% as compared with controls. At the same time, activities of trypsin and LDHI were increased in blood serum. The data obtained suggest that activation of proteases occurring during the stress led to increased hydrolysis of base components of glycocalyx and to impairment of the cardiomyocyte sarcolemma. These phenomena appear to be responsible for the post-stress deterioration of heart muscle contractile functions.
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Meerson, F. Z., Saulia, A. I., Gudumak, V. S. (1985). Role of sialic acid loss in the myocardium in depressing the contractile function of the heart muscle during stress. Voprosy Meditsinskoi Khimii, 31(2), 118-120.
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