VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Pentose monophoshate pathway and the glutathione system in physiological pregnancy

   
D'iakova N.G., Chernyshov V.G.
PubMed Id: 4002657
Year: 1985  Volume: 31  Issue: 2  Pages: 33-36
At the second and third trimesters of pregnancy an increase in activity of hexokinase, glucose-6-phosphate-(G6PD) and 6-phosphogluconate dehydrogenases (6-PDG) occurred simultaneously with a decrease in concentrations of NADPH2 by 26%, ATP by 17% and an increase in NADP by 10-15% in the pregnant women. Total amount of nicotinamide adenine dinucleotide phosphate was unaltered and constituted 0.082-0.075 mmole/L in erythrocytes from both pregnant and nonpregnant women. Activities of hexose monophosphate and glycolytic pathways of glucose metabolism appear to increase in erythrocytes under conditions of normal pregnancy. Concentration of oxidized glutathione tended to increase in the pregnant women, suggesting a possibility of the hexose monophosphate shunt activation.
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D'iakova N.G., Chernyshov V.G. (1985) Voprosy meditsinskoi khimii, 31(2), 33-36.
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