VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Additive nature of the stimulating effects of alloxan diabetes and fasting on the specific binding of insulin with its receptors in the plasma membranes of adipose and hepatic cells in the rat

   
Bezdrobnyĭ I.V., Evdokimova N.Yu., Efimov A.S.
PubMed Id: 3890365
Year: 1985  Volume: 31  Issue: 2  Pages: 46-51
Properties of insulin receptors were studied in rat fatty tissue and in plasmatic membranes of liver cells under conditions of alloxan diabetes (within 3 days) and in fasting (within 2 days) as well as under conditions of simultaneous effect of these factors. In the diabetes amount of receptors in plasmatic membranes of both these tissues, affinity of fatty cell membranes as well as amount of the receptors and their specific affinity in hepatic cell membranes were increased. Specific binding of insulin was distinctly increased under conditions of simultaneous influence of diabetes and fasting due to elevation in content of the receptors in liver cell membranes and in both their content and affinity in fatty cell membranes. The data obtained suggest that alloxan diabetes and fasting caused additive effect on expression of insulin receptors in fatty and hepatic cell plasmatic membranes as well as that the content of receptors on the cell surface was regulated by means of several mechanisms.
Download PDF:
Citation:

Bezdrobnyĭ, I. V., Evdokimova, N. Yu., Efimov, A. S. (1985). Additive nature of the stimulating effects of alloxan diabetes and fasting on the specific binding of insulin with its receptors in the plasma membranes of adipose and hepatic cells in the rat. Voprosy meditsinskoi khimii, 31(2), 46-51.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)