VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Insulin receptors of adipose tissue in patients newly diagnosed with insulin-dependent diabetes mellitus

   
Evdokimova N.Yu., Efimov A.S., Bezdrobnyĭ I.V.
PubMed Id: 3890366
Year: 1985  Volume: 31  Issue: 2  Pages: 64-68
Binding of insulin to fatty cell plasmatic membranes in 10 patients with insulin-dependent diabetes mellitus exhibited high variability. The patients were divided into two groups based on the values of insulin binding. In the first group, comprising 3 patients, specific binding of insulin was below the values found in healthy persons; this phenomenon occurred only due to a decrease in content of insulin receptors. In the second group (7 patients) specific binding of insulin exceeded the values of controls; in this case an increase in affinity of the receptors was observed. These results suggest that insulin-dependent diabetes mellitus is characterized by high heterogeneity.
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Evdokimova, N. Yu., Efimov, A. S., Bezdrobnyĭ, I. V. (1985). Insulin receptors of adipose tissue in patients newly diagnosed with insulin-dependent diabetes mellitus. Voprosy meditsinskoi khimii, 31(2), 64-68.
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